ArticleLung India : official organ of Indian Chest Society
Clinical features, demography, and predictors of outcomes of SARS-CoV-2 infection at a tertiary care hospital in India: A cohort study.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of the pre-existing coronary heart disease on the prognosis of COVID-19 patients: A systematic review and meta-analysis.PloS one · 2023Pooled it
- The Role of Platelet Parameters in Predicting the Disease Severity of COVID-19 Patients: A Hospital-Based Study.Cureus · 2024Article
- Clinico-pathological study among COVID-19 patients during the second wave of COVID-19 pandemic in Andaman Nicobar Island- "A retrospective cross-sectional study".Journal of family medicine and primary care · 2022Article
- Airway management, procedural data, and in-hospital mortality records of patients undergoing surgery for mucormycosis associated with coronavirus disease (COVID-19).Journal de mycologie medicale · 2022Article
- Prognostic value of albumin-to-globulin ratio in COVID-19 patients: A systematic review and meta-analysis.Heliyon · 2022Review
- The Effectiveness of SARS-CoV-2 Vaccination in Preventing Severe Illness and Death - Real-world Data from a Cohort of Patients Hospitalized with COVID-19.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Comparison of in-hospital COVID-19 related outcomes between COVISHIELD and COVAXIN recipients.Lung India : official organ of Indian Chest SocietyArticle
- Silent Hypoxia in Coronavirus disease-2019: Is it more dangerous? -A retrospective cohort study.Lung India : official organ of Indian Chest SocietyArticle
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Abstract
backgroundThe "second wave" of the COVID-19 pandemic hit India from early April 2021 to June 2021. We describe the clinical features, treatment trends, and baseline laboratory parameters of a cohort of patients with SARS-CoV-2 infection and their association with the outcome.
methodsThis was a retrospective cohort study. Multivariate logistic regression models were fitted to identify clinical and biochemical predictors of developing hypoxia, deterioration during the hospital stay, and death.
resultsA total of 2080 patients were included. The case fatality rate was 19.5%. Among the survivors, the median duration of hospital stay was 8 (5-11) days. Out of 853 (42.3%%) of patients who had COVID-19 acute respiratory distress syndrome at presentation, 340 (39.9%) died. Patients aged >45 years had higher odds of death as compared to the 18-44 years age group. Vaccination reduced the odds of death by 40% (odds ratio [OR] [95% confidence interval [CI]]: 0.6 [0.4-0.9], P = 0.032). Patients with hyper inflammation at baseline as suggested by leukocytosis (OR [95% CI]: 2.1 [1.5-3.1], P < 0.001), raised d-dimer >500 mg/dL (OR [95% CI]: 3.2 [2.2-4.7], P < 0.001), and raised C-reactive peptide >0.5 mg/L (OR [95% CI]: 3.7 [2.2-13], P = 0.037) had higher odds of death. Patients who were admitted in the 2
conclusionThis study shows that vaccination status and early admission during the inflammatory phase can change the course of illness of these patients. Improving vaccination rates and early admission of patients with moderate and severe COVID-19 can improve the outcomes.
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