Evidence map›Paper›PMID 34974841›Full record

ArticleBMC health services research2022

Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study.

Davina Allen, Amy Lloyd, Dawn Edwards, Kerenza Hood, Chao Huang, Jacqueline Hughes, Nina Jacob, David Lacy, Yvonne Moriarty, Alison Oliver and 11 more

Abstract read
In one paragraph

Article in BMC health services research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Davina AllenSchool of Healthcare Sciences, Cardiff University, Room 13.08, Eastgate House, Newport Road, Cardiff, CF24 0AB, UK. allenda@cardiff.ac.uk.
Amy LloydCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Dawn EdwardsChildren's Services, Swansea Bay University Health Board, Swansea, UK.
Kerenza HoodCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Chao HuangHull-York Medical School, University of Hull, Hull, UK.
Jacqueline HughesCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Nina JacobCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
David LacyArrow Park Hospital, Wirral University Teaching NHS Foundation Trust, Wirral, UK.
Yvonne MoriartyCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Alison OliverNoah's Ark Children's Hospital for Wales, Cardiff and Vale University Health Board, Cardiff, UK.
Jennifer PrestonAlder Hey Clinical Research Facility, Institute in the Park, Alder Hey Children's NHS Foundation Trust, Eaton Rd, Liverpool, UK.
Gerri SeftonAlder Hey Children's Hospital, Alder Hey Children's NHS Foundation Trust, Eaton Rd, Liverpool, UK.
Ian Sinha
Richard SkoneNoah's Ark Children's Hospital for Wales, Cardiff and Vale University Health Board, Cardiff, UK.
Heather StrangeCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Khadijeh TaiyariCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Emma Thomas-JonesCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Rob TrubeyCentre for Trials Research, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, UK.
Lyvonne TumeSchool of Health and Society, University of Salford, Manchester, UK.
Colin PowellDepartment of Emergency Medicine, Sidra Medicine, Doha, Qatar.
Damian RolandPaediatric Emergency Medicine, Leicester Academic (PEMLA) Group, Emergency Department, University of Leicester, Leicester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPaediatric mortality rates in the United Kingdom are amongst the highest in Europe. Clinically missed deterioration is a contributory factor. Evidence to support any single intervention to address this problem is limited, but a cumulative body of research highlights the need for a systems approach.

methodsAn evidence-based, theoretically informed, paediatric early warning system improvement programme (PUMA Programme) was developed and implemented in two general hospitals (no onsite Paediatric Intensive Care Unit) and two tertiary hospitals (with onsite Paediatric Intensive Care Unit) in the United Kingdom. Designed to harness local expertise to implement contextually appropriate improvement initiatives, the PUMA Programme includes a propositional model of a paediatric early warning system, system assessment tools, guidance to support improvement initiatives and structured facilitation and support. Each hospital was evaluated using interrupted time series and qualitative case studies. The primary quantitative outcome was a composite metric (adverse events), representing the number of children monthly that experienced one of the following: mortality, cardiac arrest, respiratory arrest, unplanned admission to Paediatric Intensive Care Unit, or unplanned admission to Higher Dependency Unit. System changes were assessed qualitatively through observations of clinical practice and interviews with staff and parents. A qualitative evaluation of implementation processes was undertaken.

resultsAll sites assessed their paediatric early warning systems and identified areas for improvement. All made contextually appropriate system changes, despite implementation challenges. There was a decline in the adverse event rate trend in three sites; in one site where system wide changes were organisationally supported, the decline was significant (ß = -0.09 (95% CI: - 0.15, - 0.05); p = < 0.001). Changes in trends coincided with implementation of site-specific changes.

conclusionsSystem level change to improve paediatric early warning systems can bring about positive impacts on clinical outcomes, but in paediatric practice, where the patient population is smaller and clinical outcomes event rates are low, alternative outcome measures are required to support research and quality improvement beyond large specialist centres, and methodological work on rare events is indicated. With investment in the development of alternative outcome measures and methodologies, programmes like PUMA could improve mortality and morbidity in paediatrics and other patient populations.

Indexed as

Apoptosis Regulatory ProteinsPediatricsChildHospitalizationHospitalsHumansIntensive Care Units, PediatricApoptosis Regulatory ProteinsHealthcare improvementPaediatric early warning systemsQuality improvement

Identifiers

PMID34974841
PMCPMC8722056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.