Evidence map›Paper›PMID 34974660›Full record

ArticleKidney research and clinical practice2022

The effect of probiotic supplementation on systemic inflammation in dialysis patients.

Eunho Choi, Jihyun Yang, Geun-Eog Ji, Myeong Soo Park, Yeongje Seong, Se Won Oh, Myung Gyu Kim, Won Yong Cho, Sang Kyung Jo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney research and clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Eunho ChoiDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Jihyun YangDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Geun-Eog JiDepartment of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea.
Myeong Soo ParkDepartment of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea.
Yeongje SeongResearch Center, BIFIDO Co. Ltd., Hongcheon, Republic of Korea.
Se Won OhDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Myung Gyu KimDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Won Yong ChoDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Sang Kyung JoDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Korea University · KRSeoul National University · KR

Funding

National Research Foundation of Korea 2017AR1A2B2734
6 · The paper itself

Abstract

backgroundEmerging evidence suggests that intestinal dysbiosis contributes to systemic inflammation and cardiovascular diseases in dialysis patients. The purpose of this study was to evaluate the effects of probiotic supplementation on various inflammatory parameters in hemodialysis (HD) patients.

methodsTwenty-two patients with maintenance HD were enrolled. These patients were treated twice a day with 2.0 ×1010 colony forming units of a combination of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI for 3 months. The microbiome and fecal short-chain fatty acids (SCFAs) were analyzed. The percentages of CD14+ CD16+ proinflammatory monocytes and CD4+ CD25+ regulatory T-cells (Tregs) before and after probiotic supplementation were determined by flow cytometry. Serum levels of calprotectin and cytokine responses upon lipopolysaccharide (LPS) challenge were compared before and after probiotic supplementation.

resultsFecal SCFAs increased significantly after probiotic supplementation. Serum levels of calprotectin and interleukin 6 upon LPS stimulation significantly decreased. The anti-inflammatory effects of probiotics were associated with a significant increase in the percentage of CD4+ CD25+ Tregs (3.5% vs. 8.6%, p < 0.05) and also with a decrease of CD14+ CD16+ proinflammatory monocytes (310/ mm2 vs. 194/mm2 , p < 0.05).

conclusionProbiotic supplementation reduced systemic inflammatory responses in HD patients and this effect was associated with an increase in Tregs and a decrease in proinflammatory monocytes. Hence, targeting intestinal dysbiosis might be a novel strategy for decreasing inflammation and cardiovascular risks in HD patients.

Indexed as

HemodialysisInflammationMonocytesProbioticsRegulatory T-lymphocytesShort-chain fatty acids

Identifiers

PMID34974660
PMCPMC8816411
OpenAlexW3217799722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.