Evidence map›Paper›PMID 34974650›Full record

ArticleKidney research and clinical practice2022

Association between serum osteoprotegerin level and renal prognosis in nondialysis patients with chronic kidney disease in the Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease (the KNOW-CKD Study).

Tae Ryom Oh, Chana Myeong, Su Hyun Song, Hong Sang Choi, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Wookyung Chung, Kyu Hun Choi, Kook Hwan Oh and 2 more

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Article in Kidney research and clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Tae Ryom OhDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Chana MyeongDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Su Hyun SongDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Hong Sang ChoiDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Sang Heon SuhDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Chang Seong KimDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Eun Hui BaeDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Wookyung ChungDepartment of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Kyu Hun ChoiDepartment of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kook Hwan OhDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Seong Kwon MaDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Soo Wan KimDepartment of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Chonnam National University Hospital · KRGachon University · KRSeoul National University Hospital · KRYonsei University · KR

Funding

Korea Centers for Disease Control and Prevention 2011E3300300Korea Centers for Disease Control and Prevention 2012E3301100Korea Centers for Disease Control and Prevention 2013E3301600Korea Centers for Disease Control and Prevention 2013E3301601Korea Centers for Disease Control and Prevention 2013E3301602Korea Centers for Disease Control and Prevention 2016E3300200Korea Centers for Disease Control and Prevention 2016E3300201Korea Centers for Disease Control and Prevention 2016E3300202Korea Centers for Disease Control and Prevention 2019E320100Korea Centers for Disease Control and Prevention 2019E320101Korea Centers for Disease Control and Prevention 2019E320102Ministry of Health and Welfare HR20C0021
6 · The paper itself

Abstract

backgroundOsteoprotegerin is an important regulator of bone metabolism and vascular calcification. The association between serum osteoprotegerin level and chronic kidney disease (CKD) progression has not been elucidated. We investigated the prognostic value of serum osteoprotegerin levels in nondialysis CKD patients.

methodsWe analyzed 2,082 patients enrolled in the Korean Cohort Study for Outcomes in Patients with CKD between 2011 and 2016. Patients were divided into quartiles by their serum osteoprotegerin levels. The primary outcome was the occurrence of ≥1 of the following: dialysis initiation, kidney transplantation, a two-fold increase in serum creatinine level from baseline, or a 50% decrease in the estimated glomerular filtration rate (eGFR). Cox proportional hazard regression models were used to investigate the prognostic value of the serum osteoprotegerin level to CKD progression.

resultsThe median follow-up period was 48.9 months, and 641 patients (30.8%) experienced the primary outcome. The hazard ratio of serum osteoprotegerin for renal progression in the full extended Cox proportional hazard model was 1.064 (95% confidence interval, 1.041-1.088). Subgroup analyses by age, presence of diabetes, and eGFR showed significant results consistent with the overall analysis results.

conclusionSerum osteoprotegerin level is independently associated with renal prognosis and could have prognostic importance in CKD progression.

Indexed as

Chronic kidney disease-mineral and bone disorderChronic renal insufficiencyOsteoprotegerinPrognosisRenal insufficiency

Identifiers

PMID34974650
PMCPMC8995484
OpenAlexW4200113117

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.