ArticleCerebral cortex (New York, N.Y. : 1991)2022
Dynamic subcortical modulators of human default mode network function.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder.NeuroImage. Clinical · 2026Article
- Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus.Frontiers in neuroscience · 2026Article
- Review
- Ventral pallidum efferent pathways via mediodorsal thalamus and lateral habenula mediate default mode network regulation.iScience · 2025Article
- Role of the rostral anterior cingulate cortex in emotion processing in Treatment Resistant Depression.Translational psychiatry · 2025Article
- γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.Military Medical Research · 2025Review
- GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli.Communications biology · 2025Article
- Changes in neurotransmitter-related functional connectivity along the Alzheimer's disease continuum.Brain communications · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mediodorsal thalamus and ventral pallidum contribute to subcortical regulation of the default mode network.Communications biology · 2024Article
- Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression.PLoS computational biology · 2024Article
- The subcortical default mode network and Alzheimer's disease: a systematic review and meta-analysis.Brain communications · 2024Article
- Altered task-related decoupling of the rostral anterior cingulate cortex in depression.NeuroImage. Clinical · 2024Article
- A new causal centrality measure reveals the prominent role of subcortical structures in the causal architecture of the extended default mode network.Brain structure & function · 2023Article
- Thalamocortical Mechanisms Underlying Real and Imagined Acupuncture.Biomedicines · 2023Article
- Differential engagement of the posterior cingulate cortex during cognitive restructuring of negative self- and social beliefs.Social cognitive and affective neuroscience · 2023Article
- The Role of the Left Inferior Frontal Gyrus in Introspection during Verbal Communication.Brain sciences · 2023Article
- Connectome-based predictive modelling can predict follow-up craving after abstinence in individuals with opioid use disorders.General psychiatry · 2023Article
- Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats.Alzheimer's research & therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain's "default mode network" (DMN) enables flexible switching between internally and externally focused cognition. Precisely how this modulation occurs is not well understood, although it may involve key subcortical mechanisms, including hypothesized influences from the basal forebrain (BF) and mediodorsal thalamus (MD). Here, we used ultra-high field (7 T) functional magnetic resonance imaging to examine the involvement of the BF and MD across states of task-induced DMN activity modulation. Specifically, we mapped DMN activity suppression ("deactivation") when participants transitioned between rest and externally focused task performance, as well as DMN activity engagement ("activation") when task performance was internally (i.e., self) focused. Consistent with recent rodent studies, the BF showed overall activity suppression with DMN cortical regions when comparing the rest to external task conditions. Further analyses, including dynamic causal modeling, confirmed that the BF drove changes in DMN cortical activity during these rest-to-task transitions. The MD, by comparison, was specifically engaged during internally focused cognition and demonstrated a broad excitatory influence on DMN cortical activation. These results provide the first direct evidence in humans of distinct BF and thalamic circuit influences on the control of DMN function and suggest novel mechanistic avenues for ongoing translational research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.