Evidence map›Paper›PMID 34974438›Full record

Observational studyJournal of Parkinson's disease2022

Outcomes Impacting Quality of Life in Advanced Parkinson's Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel.

Norbert Kovács, Lars Bergmann, Marieta Anca-Herschkovitsch, Esther Cubo, Thomas L Davis, Robert Iansek, Mustafa S Siddiqui, Mihaela Simu, David G Standaert, K Ray Chaudhuri and 5 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Observational
  6. Observational
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 9 countries.

Norbert KovácsUniversity of Pécs, Medical School, Pécs, Hungary.
Lars BergmannAbbVie Inc., North Chicago, IL, USA.
Marieta Anca-HerschkovitschEdith Wolfson Medical Center, Holon, Israel.
Esther CuboNeurology Department, Hospital Universitario Burgos, Burgos, Spain.
Thomas L DavisVanderbilt University Medical Center, Nashville, TN, USA.
Robert IansekKingston Centre, Monash Health, Melbourne, Australia.
Mustafa S SiddiquiWake Forest School of Medicine, Winston Salem, NC, USA.
Mihaela SimuVictor Babes University of Medicine and Pharmacy, Timisoara, Romania.
David G StandaertUniversity of Alabama at Birmingham, Birmingham, AL, USA.
K Ray ChaudhuriParkinson's Foundation International Centre of Excellence, King's College Hospital, London, UK.
Paul BourgeoisDepartment of Neurology AZ Groeninge, Kortrijk, Belgium.
Tianming GaoAbbVie Inc., North Chicago, IL, USA.
Pavnit KukrejaAbbVie Inc., North Chicago, IL, USA.
Francesco E PontieriSapienza University of Rome, Rome, Italy.
Jason AldredSelkirk Neurology, Spokane, Washington, USA.
AbbVie (United States) · USAZ Groeninge · BEFondazione Santa Lucia · ITHospital Universitario de Burgos · ESKing's College London · GBMonash Health · AUNeurology, Inc · USUniversity of Alabama at Birmingham · USUniversity of Pecs · HUVanderbilt University Medical Center · USVictor Babeș University of Medicine and Pharmacy Timișoara · ROWake Forest University · USWolfson Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is believed that motor symptoms, including dyskinesia, and non-motor symptoms impact health-related quality of life (HRQoL) in patients with Parkinson's disease (PD), and that improvements in these metrics are correlated.

objectiveInvestigate the relationship between HRQoL and measures of PD severity and treatment efficacy, including motor and non-motor symptoms.

methodsThis was a planned investigation of an international, prospective, single-arm, post-marketing observational study of the long-term effectiveness of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Pearson correlation coefficients (PCC) were calculated for baseline and change from baseline at 12 months between HRQoL and motor and non-motor symptoms.

resultsA total of 195 patients were included. At baseline, HRQoL was moderately positively correlated with Activities of Daily Living (UPDRS II, PCC = 0.44), non-motor symptoms (0.48), and measures of sleep (0.50 and 0.40); all p < 0.001. After 12 months of treatment with LCIG, improvements in HRQoL were moderately positively correlated with improvement from baseline in non-motor symptoms (PCC = 0.42), sleep (0.54), and daytime sleepiness (0.40; all p < 0.001), and weakly correlated with improvement in dyskinesia signs and symptoms (PCC = 0.23; p = 0.011). Improvement in HRQoL was not correlated with improvements in OFF time or dyskinesia time.

conclusionBoth at baseline and for change from baseline at 12 months, HRQoL was correlated with baseline and change from baseline in dyskinesia, Activities of Daily Living, and non-motor symptoms, including sleep; but not with baseline or change in OFF time.

Indexed as

CarbidopaLevodopaParkinson DiseaseActivities of Daily LivingAntiparkinson AgentsDrug CombinationsDyskinesiasGelsHumansProspective StudiesQuality of LifeAntiparkinson AgentsCarbidopaDrug CombinationsGelsLevodopaDyskinesiahealth-related quality of lifelevodopa-carbidopa intestinal gelnon-motor symptomsParkinson’s disease

Identifiers

PMID34974438
PMCPMC9108584
OpenAlexW4206669747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.