Evidence map›Paper›PMID 34974380›Full record

ReviewCurrent opinion in virology2022

Harnessing physicochemical properties of virus capsids for designing enzyme confined nanocompartments.

Masaki Uchida, Elia Manzo, Dustin Echeveria, Sophie Jiménez, Logan Lovell

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Encapsulin cargo loading: progress and potential.Journal of materials chemistry. B · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Masaki UchidaDepartment of Chemistry and Biochemistry, California State University, Fresno, 2555 E. San Ramon Ave., Fresno, CA 93740, USA. Electronic address: muchida@mail.fresnostate.edu.
Elia ManzoDepartment of Chemistry and Biochemistry, California State University, Fresno, 2555 E. San Ramon Ave., Fresno, CA 93740, USA.
Dustin EcheveriaDepartment of Chemistry and Biochemistry, California State University, Fresno, 2555 E. San Ramon Ave., Fresno, CA 93740, USA.
Sophie JiménezDepartment of Chemistry and Biochemistry, California State University, Fresno, 2555 E. San Ramon Ave., Fresno, CA 93740, USA.
Logan LovellDepartment of Chemistry and Biochemistry, California State University, Fresno, 2555 E. San Ramon Ave., Fresno, CA 93740, USA.

Funding

Introduction to Quantitative Genomic Analysis - A CUREs ApproachR25GM131956 · NIGMS · CALIFORNIA STATE UNIVERSITY FRESNO · PI KRISHNAN, VISWANATHAN V · 2019 to 2023
$2.5M
Fresno State and UC Merced Bridges to the Doctorate Program in Biomedical and Behavioral SciencesR25GM115293 · NIGMS · CALIFORNIA STATE UNIVERSITY FRESNO · PI KRISHNAN, VISWANATHAN V, LIWANG, ANDY · 2015 to 2019
$1.2M
Development of Research And Writing Skills (DRAWS): A tool for broader assessment to enhance research and research trainingT32GM137948 · NIGMS · CALIFORNIA STATE UNIVERSITY FRESNO · PI CARVAJAL CARMONA, LUIS GUILLERMO, KRISHNAN, VISWANATHAN V · 2020 to 2024
$1.1M
NIGMS NIH HHS R25 GM115293NIGMS NIH HHS R25 GM131956NIGMS NIH HHS T32 GM137948
6 · The paper itself

Abstract

Viruses have drawn significant scientific interest from a wide variety of disciplines beyond virology because of their elegant architectures and delicately balanced activities. A virus-like particle (VLP), a noninfectious protein cage derived from viruses or other cage-forming proteins, has been exploited as a nano-scale platform for bioinspired engineering and synthetic manipulation with a range of applications. Encapsulation of functional proteins, especially enzymes, is an emerging use of VLPs that is promising not only for developing efficient and robust catalytic materials, but also for providing fundamental insights into the effects of enzyme compartmentalization commonly observed in cells. This review highlights recent advances in employing VLPs as a container for confining enzymes. To accomplish larger and more controlled enzyme loading, various different enzyme encapsulation strategies have been developed; many of these strategies are inspired from assembly and genome loading mechanisms of viral capsids. Characterization of VLPs' physicochemical properties, such as porosity, could lead to rational manipulation and a better understanding of the catalytic behavior of the materials.

Indexed as

CapsidVirusesVirion

Identifiers

PMID34974380
PMCPMC8939255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.