ArticleNeuroImage2022
Using diffusion tensor imaging to effectively target TMS to deep brain structures.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study.Brain stimulationTrial
- Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.Nature human behaviour · 2026Article
- GABAergic ventrolateral preoptic projection to dorsomedial hypothalamus recapitulates post-ischemic neuroprotection by hypothermia.Cell death & disease · 2026Article
- Frequency and Self-Reported Outcomes of Transcranial Magnetic Stimulation for Obsessive Compulsive Disorder in the U.S. and Latin America.Revista colombiana de psiquiatria · 2026Article
- Magnetic Field-Guided Magnetic Nanoparticles as Neurotherapeutics for Neurological Disorders and Glioblastoma.Life (Basel, Switzerland) · 2026Review
- Neurodevelopmental considerations for transcranial magnetic stimulation trials in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Clinical development and guiding theory of transcranial magnetic stimulation: a literature review.Annals of medicine · 2025Review
- Overlooked features lead to divergent neurobiological interpretations of brain-based machine learning biomarkers.bioRxiv : the preprint server for biology · 2025Article
- Design, construction, and deployment of a multi-locus transcranial magnetic stimulation system for clinical use.Biomedical engineering online · 2025Article
- Toward personalized clinical interventions for perinatal depression: Leveraging precision functional mapping.Science advances · 2025Review
- Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder.Psychoradiology · 2025Review
- Precision TMS through the integration of neuroimaging and machine learning: optimizing stimulation targets for personalized treatment.Frontiers in human neuroscience · 2025Review
- Deep brain stimulation in globus pallidus internus travels to thalamus and subthalamic nuclei along physiological pathways.Frontiers in neuroscience · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a concurrent fMRI-EEG-TMS study.medRxiv : the preprint server for health sciences · 2024Article
- Engineering and Technological Advancements in Repetitive Transcranial Magnetic Stimulation (rTMS): A Five-Year Review.Brain sciences · 2024Review
- Transcranial Focused Ultrasound Targeting the Amygdala May Increase Psychophysiological and Subjective Negative Emotional Reactivity in Healthy Older Adults.Biological psychiatry global open science · 2024Article
- A review of algorithms and software for real-time electric field modeling techniques for transcranial magnetic stimulation.Biomedical engineering letters · 2024Review
- Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography.Molecular psychiatry · 2024Article
- Electric Field Modeling in Personalizing Transcranial Magnetic Stimulation Interventions.Biological psychiatry · 2024Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
TMS has become a powerful tool to explore cortical function, and in parallel has proven promising in the development of therapies for various psychiatric and neurological disorders. Unfortunately, much of the inference of the direct effects of TMS has been assumed to be limited to the area a few centimeters beneath the scalp, though clearly more distant regions are likely to be influenced by structurally connected stimulation sites. In this study, we sought to develop a novel paradigm to individualize TMS coil placement to non-invasively achieve activation of specific deep brain targets of relevance to the treatment of psychiatric disorders. In ten subjects, structural diffusion imaging tractography data were used to identify an accessible cortical target in the right frontal pole that demonstrated both anatomic and functional connectivity to right Brodmann area 25 (BA25). Concurrent TMS-fMRI interleaving was used with a series of single, interleaved TMS pulses applied to the right frontal pole at four intensity levels ranging from 80% to 140% of motor threshold. In nine of ten subjects, TMS to the individualized frontal pole sites resulted in significant linear increase in BOLD activation of BA25 with increasing TMS intensity. The reliable activation of BA25 in a dosage-dependent manner suggests the possibility that the careful combination of imaging with TMS can make use of network properties to help overcome depth limitations and allow noninvasive brain stimulation to influence deep brain structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.