Evidence map›Paper›PMID 34973457›Full record

ReviewAgeing research reviews2022

Toward noninvasive brain stimulation 2.0 in Alzheimer's disease.

Arianna Menardi, Simone Rossi, Giacomo Koch, Harald Hampel, Andrea Vergallo, Michael A Nitsche, Yaakov Stern, Barbara Borroni, Stefano F Cappa, Maria Cotelli and 12 more

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 56 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 7 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05999916 nacompletednot on this mapstarted 2023, after this paper: background citation

A Prospective, Single-Arm, Monocentric Pilot Study to Evaluate the Safety and Feasibility of Transcranial Alternate Current Stimulation With the Miamind Neurostimulator in Healthy Participants

TypeinterventionalSponsorBottneuro AGRan2023 to 2024Enrolled8ConditionsHealthy Participants, Healthy PopulationArmsPersonalized Miamind Neurostimulator
NCT07316413 narecruitingnot on this mapstarted 2025, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration

TypeinterventionalSponsorUniversità degli Studi di BresciaRan2025 to 2029Enrolled120ConditionsFTLD, FTD, bvFTD, PPAArmsTheta burst stimulation, Sham Theta burst stimulation
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 7 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Effects of transcranial alternating current stimulation on cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Pooled it
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  5. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on global cognitive function of elderly in mild to moderate Alzheimer's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  6. Pooled it
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  8. Review
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  13. Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  14. Article
  15. Article
  16. An update on the effects of cerebellar transcranial magnetic stimulation on cognitive function.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 18 institutions in 5 countries.

Arianna MenardiPrecision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Padova Neuroscience Center & Department of Neuroscience, University of Padova, PD, Italy.
Simone RossiSiena Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy.
Giacomo KochNoninvasive Brain Stimulation Unit, Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy.
Harald HampelSorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, F-75013 Paris, France.
Andrea VergalloSorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, F-75013 Paris, France.
Michael A NitscheDepartment of Psychology and Neurosiences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany; Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany.
Yaakov SternDepartments of Neurology, Psychiatry and Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Barbara BorroniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Stefano F CappaInstitute for Advanced Study-IUSS Pavia, Pavia, Italy; IRCCS Mondino Foundation, Pavia, Italy.
Maria CotelliNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Giulio RuffiniNeuroelectrics Corporation, 210 Broadway, 02139 Cambridge, MA, USA.
Georges El-FakhriGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Paolo M RossiniDepartment of Neuroscience & Neurorehabilitation, IRCCS San Raffaele-Pisana, Rome, Italy.
Brad DickersonFrontotemporal Disorders Unit & Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Andrea AntalDepartment of Clinical Neurophysiology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Claudio BabiloniDepartment of Physiology and Pharmacology "Erspamer", Sapienza University of Rome, Rome, Italy; San Raffaele of Cassino, Cassino, Italy.
Jean-Pascal LefaucheurENT Team, EA4391, Faculty of Medicine, Paris Est Créteil University, Créteil, France; Clinical Neurophysiology Unit, Department of Physiology, Henri Mondor Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France.
Bruno DuboisSorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, Paris, France; Brain & Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225, Boulevard de l'hôpital, Paris, France; Department of Neurology, Institute of Memory and Alzheimer's Disease (IM2A), Pitié-Salpêtrière Hospital, AP-HP, Boulevard de l'hôpital, Paris, France.
Gustavo DecoCenter for Brain and Cognition, Department of Technology and Information, Universitat Pompeu Fabra, Carrer Tànger, 122-140, 08018 Barcelona, Spain; Institució Catalana de la Recerca i Estudis Avançats, Universitat Barcelona, Passeig Lluís Companys 23, 08010 Barcelona, Spain.
Ulf ZiemannDepartment of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.
Alvaro Pascual-LeoneDepartment of Neurology, Harvard Medical School, Boston, MA, USA; Hinda and Arthur Marcus Institute for Aging Research and Center for Memory Health, Hebrew Senior Life, Boston, MA, USA; Guttmann Brain Health Institute, Institut Guttmann, Universitat Autonoma, Barcelona, Spain.
Emiliano SantarnecchiPrecision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: esantarnecchi@mgh.harvard.edu.
Harvard University · USAssistance Publique – Hôpitaux de Paris · FRAlzheimer Precision MedicineCentro San Giovanni di Dio Fatebenefratelli · ITColumbia University · USFondazione Santa Lucia · ITGordon Center for Medical Imaging · USHebrew SeniorLife · USHertie Institute for Clinical Brain Research · DEInstitució Catalana de Recerca i Estudis Avançats · ESIRCCS Ospedale San Raffaele · ITIstituto Universitario di Studi Superiori di Pavia · ITTU Dortmund University · DEUniversità degli studi di Cassino e del Lazio Meridionale · ITUniversitätsmedizin Göttingen · DEUniversité Paris-Est Créteil · FRUniversity of Brescia · ITUniversity of Siena · IT

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Gamma Induction for Amyloid Clearance in Alzheimer’s DiseaseR01AG060981 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SANTARNECCHI, EMILIANO · 2019 to 2023
$3.5M
NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG060981NIBIB NIH HHS P41 EB022544
6 · The paper itself

Abstract

Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cognitive functions. Nevertheless, current approaches suffer from some limitations. In this study, we review and discuss experimental NiBS applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleep-related memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection. The present work aims to stress the importance of multidisciplinary, translational, model-driven interventions for precision medicine approaches in AD.

Indexed as

Alzheimer DiseaseTranscranial Direct Current StimulationBrainCognitionHumansTranscranial Magnetic StimulationAlzheimer’s diseaseNoninvasive brain stimulationPrecision medicineTranscranial electrical stimulationTranscranial magnetic stimulation

Identifiers

PMID34973457
PMCPMC8858588
OpenAlexW4200144532

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.