Evidence map›Paper›PMID 34973084›Full record

ArticleCancer immunology, immunotherapy : CII2022

Blocking GARP-mediated activation of TGF-β1 did not alter innate or adaptive immune responses to bacterial infection or protein immunization in mice.

Mélanie Gaignage, Xuhao Zhang, Julie Stockis, Olivier Dedobbeleer, Camille Michiels, Perrine Cochez, Laure Dumoutier, Pierre G Coulie, Sophie Lucas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mélanie Gaignagede Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Xuhao Zhangde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Julie Stockisde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Olivier Dedobbeleerde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Camille Michielsde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Perrine Cochezde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Laure Dumoutierde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Pierre G Couliede Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium.
Sophie Lucasde Duve Institute, Université Catholique de Louvain, avenue Hippocrate 74, B1.74.04, 1200, Brussels, Belgium. sophie.lucas@uclouvain.be.ORCID http://orcid.org/0000-0003-1287-7996
de Duve Institute · BE

Funding

ARC Actions de Recherche Concertees 14/19-056European Research Council TARG-SUP 682818Fondation Contre le Cancer (FCC) F/2016/837Fonds De La Recherche Scientifique - FNRS T.0089.16WALinnov, IMMUCAN 1610119WELBIO Walloon Excellence in Life Sciences and Biotechnology CR-2019A-02
6 · The paper itself

Abstract

Transmembrane protein GARP binds latent TGF-β1 to form GARP:(latent)TGF-β1 complexes on the surface of several cell types including Tregs, B-cells, and platelets. Upon stimulation, these cells release active TGF-β1. Blocking TGF-β1 activation by Tregs with anti-GARP:TGF-β1 mAbs overcomes resistance to PD1/PD-L1 blockade and induces immune-mediated regressions of murine tumors, indicating that Treg-derived TGF-β1 inhibits anti-tumor immunity. TGF-β1 exerts a vast array of effects on immune responses. For example, it favors differentiation of T

Indexed as

Adaptive ImmunityBacterial InfectionsMembrane ProteinsTransforming Growth Factor beta1AnimalsAntibodies, MonoclonalImmunityImmunizationMiceT-Lymphocytes, RegulatoryAntibodies, MonoclonalLrrc32 protein, mouseMembrane ProteinsTransforming Growth Factor beta1Citrobacter rodentiumGARPIntestinal bacterial infectionsMonoclonal antibodyProtein immunizationTGF-β1

Identifiers

PMID34973084
PMCPMC9294018
OpenAlexW4205202313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.