Evidence map›Paper›PMID 34973016›Full record

ArticleAdvances in experimental medicine and biology2021

Adiponectin and Its Effects on Acute Leukemia Cells: An Experimental and Bioinformatics Approach.

Athanasios N Tsartsalis, Anna Tagka, Athanasios Kotoulas, Daphne Mirkopoulou, Styliani A Geronikolou, Lambrou G

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Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Athanasios N TsartsalisNaval Hospital of Athens, Department of Endocrinology Diabetes and Metabolism, Athens, Greece.
Anna TagkaFirst Department of Dermatology and Venereology, "Andreas Syggros" Hospital National and Kapodistrian University of Athens, Athens, Greece.
Athanasios KotoulasNational Technical University of Athens, School of Electrical and Computer Engineering Biomedical Engineering Laboratory, Athens, Greece.
Daphne MirkopoulouFirst Propaedeutic and Internal Medicine Department, Aristotelian University if Thessaloniki, General Hospital of Thessaloniki, Thessaloniki, Greece.
Styliani A GeronikolouBiomedical Research Foundation of Academy of Athens, Clinical, Translational, Experimental Surgery Research Centerment of Pediatrics, Athens, Greece.
Lambrou GNational and Kapodistrian University of Athens, First Department of Pediatrics, Choremeio Research Laboratory, Athens, Greece. glamprou@med.uoa.gr.
Academy of Athens · GRAndreas Sygros Hospital · GRAristotle University of Thessaloniki · GRAthens Naval & Veterans Hospital · GRNational Technical University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. It is known that deregulation of adipokine pathways is probably implicated in the ontogenesis of ALL. The present work aims at investigating the role of adiponectin and its effects on an ALL cell line. The CCRF-CEM cells were used as a model. Cells have been treated with adiponectin, with different concentrations up to 72 h. Cytotoxicity and cell cycle distribution were investigated for all concentrations using flow cytometry. Selected concentrations were also used for additional microarray analysis, using a small gene set of cancer-related genes. Lower and higher adiponectin concentrations did not produce an inhibition of proliferation, as well as an increase in cell death. It was found that adiponectin regulated differentially genes, such as CD22, CDH1, IFNG, LCK, MSH2, SPINT2, and others. At the same time, it appeared that adiponectin-related gene expression was more active on chromosomes 18 and 1. Machine learning classification algorithms showed that several genes were grouped together indicating common regulatory mechanisms. The present study showed that adiponectin is able to induce gene differential expression in leukemic cells in vitro, suggesting a possible role in the progression of leukemia. It is also an indication that more studies are required in order to further understand the role of adiponectin and adipokines in general in the role of human neoplasms.

Indexed as

AdiponectinPrecursor Cell Lymphoblastic Leukemia-LymphomaCell Line, TumorComputational BiologyHumansMembrane GlycoproteinsOncogenesAdiponectinMembrane GlycoproteinsSPINT2 protein, humanAcute lymphoblastic leukemiaAdiponectinBioinformaticsComputational analysisGene expression

Identifiers

PMID34973016
OpenAlexW4206154946

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.