Evidence map›Paper›PMID 34972842›Full record

ArticleAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2022

Effects of a National Quality Improvement Collaborative on ABCDEF Bundle Implementation.

Michele C Balas, Alai Tan, Brenda T Pun, E Wesley Ely, Shannon S Carson, Lorraine Mion, Mary Ann Barnes-Daly, Eduard E Vasilevskis

Abstract read
In one paragraph

Article in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Interprofessional Simulation-Based Training to Facilitate ABCDEF Bundle Implementation.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2025
    Article
  4. Article
  5. Patient, Practice, and Organizational Factors Associated With Early Mobility Performance in Critically Ill Adults.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Decline in Prolonged Acute Mechanical Ventilation, 2011-2019.American journal of respiratory and critical care medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele C BalasMichele C. Balas is an associate dean of research and Dorothy Hodges Olsen Distinguished Professor of Nursing at the University of Nebraska Medical Center College of Nursing, Omaha, Nebraska.
Alai TanAlai Tan is a research professor, Center for Research and Health Analytics, College of Nursing, The Ohio State University, Columbus, Ohio.
Brenda T PunBrenda T. Pun is director of data quality at the Critical Illness, Brain Dysfunction, and Survivorship Center, Vanderbilt University Medical Center, Nashville, Tennessee.
E Wesley ElyE. Wesley Ely is a professor at the Critical Illness, Brain Dysfunction, and Survivorship Center, Vanderbilt University Medical Center, and at the Tennessee Valley Veterans Affairs Geriatric Research Education and Clinical Center, Nashville, Tennessee.
Shannon S CarsonShannon S. Carson is a professor at the University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Lorraine MionLorraine Mion is a research professor, Center of Healthy Aging, Self-Management and Complex Care, The Ohio State University College of Nursing.
Mary Ann Barnes-DalyMary Ann Barnes-Daly is a clinical performance improvement consultant at Sutter Health, Sacramento California.
Eduard E VasilevskisEduard E. Vasilevskis is an associate professor, Division of General Internal Medicine and Public Health, Section of Hospital Medicine; the Center for Health Services Research; the Center for Quality Aging; and the Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, and a staff physician, Tennessee Valley Veterans Affairs Geriatric Research Education and Clinical Center.

Funding

Determinants of Implementation Success Coordinating Ventilator, Early Ambulation and Rehabilitation Efforts in the ICU (DISCOVER-ICU) studyR01HL146781 · NHLBI · OHIO STATE UNIVERSITY · PI BALAS, MICHELE CHRISTINA, MION, LORRAINE C · 2019 to 2021
$1.3M
NHLBI NIH HHS R01 HL146781
6 · The paper itself

Abstract

backgroundThe ABCDEF bundle (Assess, prevent, and manage pain and Delirium; Both spontaneous awakening and breathing trials; Choice of analgesia/sedation; Early mobility; and Family engagement) improves intensive care unit outcomes, but adoption into practice is poor.

objectiveTo assess the effect of quality improvement collaborative participation on ABCDEF bundle performance.

methodsThis interrupted time series analysis included 20 months of bundle performance data from 15 226 adults admitted to 68 US intensive care units. Segmented regression models were used to quantify complete and individual bundle element performance changes over time and compare performance patterns before (6 months) and after (14 months) collaborative initiation.

resultsComplete bundle performance rates were very low at baseline (<4%) but increased to 12% by the end. Complete bundle performance increased by 2 percentage points (SE, 0.9; P = .06) immediately after collaborative initiation. Each subsequent month was associated with an increase of 0.6 percentage points (SE, 0.2; P = .04). Performance rates increased significantly immediately after initiation for pain assessment (7.6% [SE, 2.0%], P = .002), sedation assessment (9.1% [SE, 3.7%], P = .02), and family engagement (7.8% [SE, 3%], P = .02) and then increased monthly at the same speed as the trend in the baseline period. Performance rates were lowest for spontaneous awakening/breathing trials and early mobility.

conclusionsQuality improvement collaborative participation resulted in clinically meaningful, but small and variable, improvements in bundle performance. Opportunities remain to improve adoption of sedation, mechanical ventilation, and early mobility practices.

Indexed as

Patient Care BundlesQuality ImprovementAdultCritical CareCritical IllnessHumansIntensive Care UnitsVentilator Weaning

Identifiers

PMID34972842
PMCPMC9972543

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.