Trial reportThe British journal of general practice : the journal of the Royal College of General Practitioners2022
Non-speculum sampling approaches for cervical screening in older women: randomised controlled trial.
Trial report in The British journal of general practice : the journal of the Royal College of General Practitioners, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cervical cancer screening strategies in women 65 years and older in the human papillomavirus era: A systematic review and meta-analysis of human papillomavirus-based testing and self-sampling approaches.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Pooled it
- Identifying optimum implementation for human papillomavirus self-sampling in underserved communities: A systematic review.Journal of medical screening · 2025Pooled it
- Invitation strategy of vaginal HPV self-sampling to improve participation in cervical cancer screening: a systematic review and meta-analysis of randomized trials.BMC public health · 2024Pooled it
- Does self-sampling for human papilloma virus testing have the potential to increase cervical cancer screening? An updated meta-analysis of observational studies and randomized clinical trials.Frontiers in public health · 2022Pooled it
- The Use of First-Void Urine to Screen Women Aged 60-79 for HPV in the UK: The Catch-Up Screen Study.BJOG : an international journal of obstetrics and gynaecology · 2026Trial
- Value of a catch-up HPV test in women aged 65 and above: A Danish population-based nonrandomized intervention study.PLoS medicine · 2023Trial
- Effect of Patient Characteristics on Uptake of Screening Using a Mailed Human Papillomavirus Self-sampling Kit: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Acceptability of, and preference for, human papillomavirus self-sampling for physically Disabled women: A cross-sectional survey.Journal of medical screening · 2026Article
- Clinician and patient experiences with opportunistic offer of HPV self-testing in Aotearoa New Zealand primary care clinics: interview and survey findings.BMC primary care · 2026Article
- Patient vs. clinician-collected cervical cytology for screening for CIN: a systematic review and meta-analysis.AJOG global reports · 2025Review
- Acceptability of Self-Sampling for Cervical Screening in Ethnically Diverse Groups in Northwest England: A Focus Group Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Cervical Cancer Biomarkers in Non-Cervical Samples: Emerging Tools for Diagnosis and Prognosis.International journal of molecular sciences · 2025Review
- Experiences and Preferences Reported with an At-Home Self-Collection Device Compared with In-Clinic Speculum-Based Cervical Cancer Screening in the United States.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Experiences and Perceptions of Cervical Cancer Screening Using Self-Sampling among Under-Screened Women in Flanders.Healthcare (Basel, Switzerland) · 2024Article
- Experiences of Self-Sampling and Future Screening Preferences in Non-Attenders Who Returned an HPV Vaginal Self-Sample in the YouScreen Study: Findings From a Cross-Sectional Questionnaire.Health expectations : an international journal of public participation in health care and health policy · 2024Article
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- The acceptability of, and informational needs related to, self-collection cervical screening among women of Indian descent living in Victoria, Australia: A qualitative study.Health expectations : an international journal of public participation in health care and health policy · 2024Article
- Top studies of 2022 relevant to primary care: From the PEER team.Canadian family physician Medecin de famille canadien · 2023Review
- Self-sampling for cervical screening offered at the point of invitation: A cross-sectional study of preferences in England.Journal of medical screening · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCervical cancer disproportionately affects women ≥65 years, especially those not screened regularly. Speculum use is a key barrier.
aimTo assess if offering non-speculum clinician-taken sampling and self-sampling increases uptake for lapsed attenders aged 50-64 years. DESIGN AND
settingPragmatic randomised control trial conducted at 10 general practices in East London, UK.
methodParticipants were 784 women aged 50-64 years, last screened 6-15 years before randomisation. Intervention participants received a letter offering the choice of non-speculum clinician- or self-sampling. Control participants received usual care. The main outcome measure was uptake within 4 months.
resultsScreening uptake 4 months after randomisation was significantly higher in the intervention arm: 20.4% (
conclusionOffering non-speculum clinician-taken sampling and self-sampling substantially increases uptake in older lapsed attendee women. Non-speculum clinician sampling appeals to women who dislike the speculum but still prefer a clinician to take their sample. Providing a choice of screening modality may be important for optimising cervical screening uptake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.