Evidence map›Paper›PMID 34972738›Full record

ArticleIn vivo (Athens, Greece)

Early Occurrence of Adverse Events in Hospitalized Patients With COVID-19 and Beneficial Effect of Anticoagulation.

Evangelos Dimakakos, Anastasios Kollias, Vasiliki Rapti, Konstantinos G Kyriakoulis, Ioannis P Trontzas, Mahmoud M Abdelrasoul, Stavroula Zanelli, Konstantinos Leontis, Katerina Argyraki, Katerina Dimakou and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Evangelos Dimakakos3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Anastasios Kollias3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Vasiliki Rapti3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Konstantinos G Kyriakoulis3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Ioannis P Trontzas3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece; john-tron@hotmail.com.
Mahmoud M AbdelrasoulDivine Providence Hospital "Pammakaristos", Department of Internal Medicine, Athens, Greece.
Stavroula Zanelli1 Department of Infectious Diseases, Sotiria General Hospital, Athens, Greece.
Konstantinos Leontis3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Katerina Argyraki1 Department of Infectious Diseases, Sotiria General Hospital, Athens, Greece.
Katerina Dimakou5 Respiratory Medicine Department, Sotiria General Hospital, Athens, Greece.
Georgios Tsoukalas4 Respiratory Medicine Department, Sotiria General Hospital, Athens, Greece.
Kalomira Athanasiou3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Thomas Nitsotolis3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Konstantinos N Syrigos3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
Garyphallia Poulakou3 Third Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria Hospital, Athens, Greece.
National and Kapodistrian University of Athens · GRSotiria General Hospital · GRPammakaristos Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study analyzed the characteristics of patients with COVID-19 with major events during the first days of hospitalization. PATIENTS AND

methodsThis is a retrospective analysis of prospectively collected data from consecutive patients admitted to two hospitals in Athens, Greece. The characteristics of patients with COVID-19 who suffered the primary endpoint (venous thromboembolic events, intubation, and death) during the first days of hospitalization were analyzed.

resultsAmong 95 patients included in the analysis, 21 presented with major adverse events during a median follow-up of 13 days. More than 50% of these patients presented with a major event during the first 3 days. Anticoagulation treatment was inversely associated with the cumulative incidence of the primary endpoint [hazard ratio=0.16 (95% confidence interval=0.06-0.47)]. Patients with major events were older, with lower baseline SatO

conclusionMajor adverse events may occur early in hospitalized patients with COVID-19 with a high-risk profile. Anticoagulation treatment appears to reduce this risk and thus prompt thromboprophylaxis should be employed in these patients.

Indexed as

COVID-19Venous ThromboembolismAnticoagulantsHumansRetrospective StudiesSARS-CoV-2Anticoagulantsanticoagulation treatmentCOVID-19high risk factorshome-treatedthromboprophylaxis

Identifiers

PMID34972738
PMCPMC8765153
OpenAlexW4206569373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.