ArticleOccupational and environmental medicine2022
Markers of kidney tubular and interstitial injury and function among sugarcane workers with cross-harvest serum creatinine elevation.
Article in Occupational and environmental medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Atrazine use and markers of kidney function and nephrotoxicity among male farmers in the Biomarkers of Exposure and Effect in Agriculture Study.Occupational and environmental medicine · 2025Article
- One day of environment-induced heat stress causes injury to the murine kidney.Experimental physiology · 2025Article
- NT-proBNP as a Biomarker in MGUS and Multiple Myeloma: A Retrospective Analysis.Journal of clinical medicine · 2025Article
- Article
- Low albumin-to-creatinine ratios (ACR) are associated with poor outcomes in cancer patients.BMC cancer · 2025Article
- Point-of-care testing device platform for the determination of creatinine on an enzyme@CS/PB/MXene@AuNP-based screen-printed carbon electrode.Mikrochimica acta · 2024Article
- Systematic Review of Kidney Injury Biomarkers for the Evaluation of CKD of Uncertain Etiology.Kidney international reports · 2024Article
- Association of cardio-renal biomarkers and mortality in the U.S.: a prospective cohort study.Cardiovascular diabetology · 2023Article
- Prevalence of kidney disease of unknown etiology in agricultural workers, Guatemala.Revista panamericana de salud publica = Pan American journal of public health · 2023Article
- Point-of-care biomarkers for prediction of kidney function trajectory among sugarcane cutters: a comparative test accuracy study.BMJ open · 2022Article
- Large difference but high correlation between creatinine and cystatin C estimated glomerular filtration rate in Mesoamerican sugarcane cutters.Occupational and environmental medicine · 2022Article
- Where do you live and what do you do? Two questions that might impact your kidney health.Frontiers in nephrology · 2022Review
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesSerum creatinine (SCr) is a routine marker of kidney injury but also increases with dehydration and muscular work. This study was to elucidate whether increase in SCr is associated with more specific markers of kidney tubular and interstitial injury and function, during prolonged heat stress among workers at high risk of chronic kidney disease of non-traditional origin (CKDnt).
methodsUrine monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), calbindin, glutathione S-transferase-π (GST-π), clusterin, interleukin 18 and albumin, fractional excretion of potassium (FEK), blood haemoglobin, serum potassium, ferritin and erythropoietin were measured before and after harvest in a sample of 30 workers with a ≥0.3 mg/dL SCr increase across harvest (cases), and 53 workers with stable SCr (controls).
resultsUrine MCP-1 (p for differential cross-harvest trend <0.001), KIM-1 (p=0.002), calbindin (p=0.02), GST-π (p=0.04), albumin (p=0.001) and FEK (p<0.001) increased in cases, whereas blood haemoglobin (p<0.001) and serum erythropoietin (p<0.001) decreased.
conclusionSeveral markers of tubular and interstitial injury and function changed as SCr increased across a harvest season, supporting the use of SCr as an indicator of kidney injury in physically active workers regularly exposed to heat stress. Repeated injury similar to that described here, and continued work under strenuous and hot conditions with similarly elevated injury markers is likely to worsen and possibly initiate CKDnt.
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