Evidence map›Paper›PMID 34972190›Full record

ArticlePloS one2021

COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery.

Michael R Mercier, Anoop R Galivanche, Jordan P Brand, Neil Pathak, Michael J Medvecky, Arya G Varthi, Lee E Rubin, Jonathan N Grauer

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Increased Odds of Perioperative Complications Following Lumbar Diskectomy Among Patients With a Colostomy.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michael R MercierDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Anoop R GalivancheDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Jordan P BrandDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Neil PathakDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Michael J MedveckyDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Arya G VarthiDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Lee E RubinDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.
Jonathan N GrauerDepartment of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States of America.ORCID 0000-0002-2626-7278
Yale University · US

Funding

NIA Short Term Research Training: Students in Health Professional SchoolsT35AG049685 · NIA · YALE UNIVERSITY · PI Sarwat I Chaudhry, Terri R. Fried · 2016 to 2026
$804k
NIA NIH HHS T35 AG049685
6 · The paper itself

Abstract

introductionAnkle fractures have continued to occur through the COVID pandemic and, regardless of patient COVID status, often need operative intervention for optimizing long-term outcomes. For healthcare optimization, patient counseling, and care planning, understanding if COVID-positive patients undergoing ankle fracture surgery are at increased risk for perioperative adverse outcomes is of interest.

methodsThe COVID-19 Research Database contains recent United States aggregated insurance claims. Patients who underwent ankle fracture surgery from April 1st, 2020 to June 15th, 2020 were identified. COVID status was identified by ICD coding. Demographics, comorbidities, and postoperative complications were extracted based on administrative data. COVID-positive versus negative patients were compared with univariate analyses. Propensity-score matching was done on the basis of age, sex, and comorbidities. Multivariate regression was then performed to identify risk factors independently associated with the occurrence of 30-day postoperative adverse events.

resultsIn total, 9,835 patients undergoing ankle fracture surgery were identified, of which 57 (0.58%) were COVID-positive. COVID-positive ankle fracture patients demonstrated a higher prevalence of comorbidities, including: chronic kidney disease, diabetes, hypertension, and obesity (p<0.05 for each). After propensity matching and controlling for all preoperative variables, multivariate analysis found that COVID-positive patients were at increased risk of any adverse event (odds ratio [OR] = 3.89, p = 0.002), a serious adverse event (OR = 5.48, p = 0.002), and a minor adverse event (OR = 3.10, p = 0.021). DISCUSSION: COVID-positive patients will continue to present with ankle fractures requiring operative intervention. Even after propensity matching and controlling for patient factors, COVID-positive patients were found to be at increased risk of 30-day perioperative adverse events. Not only do treatment teams need to be protected from the transmission of COVID in such situations, but the increased incidence of perioperative adverse events needs to be considered.

Indexed as

PandemicsAdolescentAdultAnkle FracturesChildChild, PreschoolCOVID-19Databases, FactualFemaleHumansInfantInfant, NewbornMaleMiddle AgedOpen Fracture ReductionPostoperative Complications

Identifiers

PMID34972190
PMCPMC8719674
OpenAlexW4206485019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.