Evidence map›Paper›PMID 34971846›Full record

ArticleNeurobiology of aging2022

Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.

Alexander G Murley, Kamen A Tsvetanov, Matthew A Rouse, P Simon Jones, Katrine Sværke, Win Li, Adrian Carpenter, James B Rowe

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexander G MurleyDepartment of Clinical Neurosciences, University of Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, UK. Electronic address: am2505@medschl.cam.ac.uk.
Kamen A TsvetanovDepartment of Clinical Neurosciences, University of Cambridge, UK.
Matthew A RouseDepartment of Clinical Neurosciences, University of Cambridge, UK.
P Simon JonesDepartment of Clinical Neurosciences, University of Cambridge, UK.
Katrine SværkeDepartment of Clinical Neurosciences, University of Cambridge, UK.
Win LiDepartment of Clinical Neurosciences, University of Cambridge, UK.
Adrian CarpenterDepartment of Clinical Neurosciences, University of Cambridge, UK.
James B RoweDepartment of Clinical Neurosciences, University of Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, UK; MRC Cognition and Brain, Sciences Unit, University of Cambridge, UK.
University of Cambridge · GBMRC Cognition and Brain Sciences Unit · GB

Funding

Medical Research Council MR/M009041/1Medical Research Council SUAG/051 G101400Wellcome Trust 103838
6 · The paper itself

Abstract

There is an urgent need for a better understanding of the pathophysiology of cognitive impairment in syndromes associated with frontotemporal lobar degeneration. Here, we used magnetic resonance spectroscopy to quantify metabolite deficits in sixty patients with a clinical syndrome associated with frontotemporal lobar degeneration (behavioral variant frontotemporal dementia n = 11, progressive supranuclear palsy n = 26, corticobasal syndrome n = 11, primary progressive aphasias n = 12), and 38 age- and sex-matched healthy controls. We measured nine metabolites in the right inferior frontal gyrus, superior temporal gyrus and right primary visual cortex. Metabolite concentrations were corrected for age, sex, and partial volume then compared with cognitive and behavioral measures using canonical correlation analysis. Metabolite concentrations varied significantly by brain region and diagnosis (region x metabolite x diagnosis interaction F

Indexed as

Proton Magnetic Resonance SpectroscopyAgedAspartic AcidBehaviorCognitionExecutive FunctionFemaleFrontotemporal Lobar DegenerationGlutamatesHumansMaleMiddle AgedPrefrontal CortexPrimary Visual CortexTemporal LobeAspartic AcidGlutamatesN-acetylaspartateBehavioral variant frontotemporal dementiaCorticobasal syndromeFrontotemporal lobar degenerationGlutamateProgressive supranuclear palsyspectroscopy

Identifiers

PMID34971846
PMCPMC8776136
OpenAlexW3210759110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.