Evidence map›Paper›PMID 34971562›Full record

ReviewStem cell reports2022

Biomanufacturing in low Earth orbit for regenerative medicine.

Arun Sharma, Rachel A Clemens, Orquidea Garcia, D Lansing Taylor, Nicole L Wagner, Kelly A Shepard, Anjali Gupta, Siobhan Malany, Alan J Grodzinsky, Mary Kearns-Jonker and 16 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  17. Public-private partnerships in fostering outer space innovations.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Arun SharmaBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: arun.sharma@cshs.org.
Rachel A ClemensAxiom Space, Inc., Houston, TX, USA.
Orquidea GarciaJohnson & Johnson 3D Printing Innovation & Customer Solutions, Johnson & Johnson Services, Inc., Irvine, CA, USA.
D Lansing TaylorUniversity of Pittsburgh Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Nicole L WagnerLambdaVision Inc., Farmington, CT, USA.
Kelly A ShepardCalifornia Institute for Regenerative Medicine, Oakland, CA, USA.
Anjali GuptaAxiom Space, Inc., Houston, TX, USA.
Siobhan MalanyDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Alan J GrodzinskyDepartments of Biological Engineering, Mechanical Engineering and Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mary Kearns-JonkerDepartment of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Devin B MairDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Deok-Ho KimDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael S RobertsCenter for the Advancement of Science in Space, Inc, Melbourne, FL, USA.
Jeanne F LoringScripps Research Institute, San Diego, CA, USA.
Jianying HuCenter for Computational Health IBM Research, Yorktown Heights, New York, NY, USA.
Lara E WarrenCenter for the Advancement of Science in Space, Inc, Melbourne, FL, USA.
Sven EenmaaCenter for the Advancement of Science in Space, Inc, Melbourne, FL, USA.
Joe BozadaJoseph M. Katz Graduate School of Business, University of Pittsburgh, Pittsburgh, PA, USA.
Eric PaljugJoseph M. Katz Graduate School of Business, University of Pittsburgh, Pittsburgh, PA, USA.
Mark RothPittsburgh, PA, USA.
Donald P TaylorThe Ohio State University, Columbus, OH, USA.
Gary RodrigueCenter for the Advancement of Science in Space, Inc, Melbourne, FL, USA.
Patrick CantiniMcGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA.
Amelia W SmithCenter for the Advancement of Science in Space, Inc, Melbourne, FL, USA.
Marc A GiulianottiCenter for the Advancement of Science in Space, Inc, Melbourne, FL, USA. Electronic address: mgiulianotti@issnationallab.org.
William R WagnerMcGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA; Departments of Surgery, Bioengineering, Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: wagnerwr@upmc.edu.

Funding

A Human iPSC-based 3D Microphysiological System for Modeling Cardiac Dysfunction in MicrogravityUH3TR003519 · NCATS · JOHNS HOPKINS UNIVERSITY · PI KIM, DEOK-HO · 2020 to 2022
$2.0M
Cartilage-Bone-Synovium MPS: Musculoskeletal Disease Biology in SpaceUH3TR002186 · NCATS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRODZINSKY, ALAN J. · 2019 to 2020
$1.5M
Cartilage-Bone-Synovium MPS: Musculoskeletal Disease Biology in SpaceUG3TR002186 · NCATS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CIRIT, MURAT, GRODZINSKY, ALAN J. · 2017 to 2018
$1.3M
NCATS NIH HHS UG3 TR002186NCATS NIH HHS UH3 TR002186NCATS NIH HHS UH3 TR003519
6 · The paper itself

Abstract

Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.

Indexed as

Biocompatible MaterialsExtraterrestrial EnvironmentManufactured MaterialsRegenerative MedicineArtificial IntelligenceAutomationBioengineeringHumansMachine LearningResearchBiocompatible Materialsbiofabricationmicrogravitymicrophysiological systemsorganoidsstem cells

Identifiers

PMID34971562
PMCPMC8758939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.