Evidence map›Paper›PMID 34971560›Full record

ArticleCell host & microbe2022

The Mouse Gastrointestinal Bacteria Catalogue enables translation between the mouse and human gut microbiotas via functional mapping.

Benjamin S Beresford-Jones, Samuel C Forster, Mark D Stares, George Notley, Elisa Viciani, Hilary P Browne, Daniel J Boehmler, Amelia T Soderholm, Nitin Kumar, Kevin Vervier and 4 more

Abstract read
In one paragraph

Article in Cell host & microbe, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Roles of the gut microbiome in weight management.Nature reviews. Microbiology · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. The OMMGut microbes · 2026
    Review
  7. Article
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  15. Increased abundance of Limosilactobacillus reuteri in the gut of selectively bred high-tameness mice and its association with behavioural changes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Benjamin S Beresford-JonesCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
Samuel C ForsterWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Mark D StaresWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
George NotleyWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Elisa VicianiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Hilary P BrowneWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Daniel J BoehmlerDonald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Amelia T SoderholmCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
Nitin KumarWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Kevin VervierWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Justin R CrossDonald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alexandre AlmeidaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; European Bioinformatics Institute, EMBL-EBI, Wellcome Genome Campus, Hinxton, UK.
Trevor D LawleyWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. Electronic address: tl2@sanger.ac.uk.
Virginia A PedicordCambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK. Electronic address: vap33@cam.ac.uk.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748Wellcome Trust
6 · The paper itself

Abstract

Human health and disease have increasingly been shown to be impacted by the gut microbiota, and mouse models are essential for investigating these effects. However, the compositions of human and mouse gut microbiotas are distinct, limiting translation of microbiota research between these hosts. To address this, we constructed the Mouse Gastrointestinal Bacteria Catalogue (MGBC), a repository of 26,640 high-quality mouse microbiota-derived bacterial genomes. This catalog enables species-level analyses for mapping functions of interest and identifying functionally equivalent taxa between the microbiotas of humans and mice. We have complemented this with a publicly deposited collection of 223 bacterial isolates, including 62 previously uncultured species, to facilitate experimental investigation of individual commensal bacteria functions in vitro and in vivo. Together, these resources provide the ability to identify and test functionally equivalent members of the host-specific gut microbiotas of humans and mice and support the informed use of mouse models in human microbiota research.

Indexed as

AnimalsBacteriaButyratesGastrointestinal MicrobiomeGenome, BacterialHumansMetagenomeMiceModels, AnimalButyratesbacteria culture collectionbutyratecommensal bacteriafunctionally equivalent speciesgut microbiotamicrobial drug metabolismmouse gut metagenomesmouse modelspublic databasetranslation between mouse and human

Identifiers

PMID34971560
PMCPMC8763404

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.