ArticleMagnetic resonance in medicine2022
Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Downfield magnetic resonance signals serve as endogenous imaging biomarkers of nucleotide metabolism in glioma.Communications biology · 2026Article
- Amide mapping in the human brain using downfield MRSI at 3 T and 7 T.Magnetic resonance in medicine · 2025Article
- Optimization ofMagnetic resonance in medicine · 2025Article
- High-field downfield MR spectroscopic imaging in the human brain.Magnetic resonance in medicine · 2024Article
- Optimization ofmedRxiv : the preprint server for health sciences · 2024Article
- Identification of new resonances in downfieldMagnetic resonance in medicine · 2023Article
- Downfield proton MRSI with whole-brain coverage at 3T.Magnetic resonance in medicine · 2023Article
- Article
- Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3 T.Magnetic resonance in medicine · 2023Article
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Authors and funding
4 authors.
Funding
Abstract
purposeTo develop an MRSI technique capable of mapping downfield proton resonances in the human brain.
methodsA spectral-spatial excitation and frequency-selective refocusing scheme, in combination with 2D phase encoding, was developed for mapping of downfield resonances without any perturbation of the water magnetization. An alternative scheme using spectral-spatial refocusing was also investigated for simultaneous detection of both downfield and upfield resonances. The method was tested in 5 healthy human volunteers.
resultsDownfield metabolite maps with a nominal spatial resolution of 1.5 cm
conclusionThe developed MRSI pulse sequence was shown to be an efficient way of rapidly mapping downfield resonances in the human brain at 3 T, maximizing sensitivity through the relaxation enhancement effect. Because the MRSI approach is efficient in terms of data collection and can be readily implemented at short TE, somewhat higher spatial resolution can be achieved than has been reported in previous single-voxel downfield MRS studies. With this approach, nine downfield resonances could be mapped in a single slice for the first time using MRSI at 3 T.
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