Evidence map›Paper›PMID 34971013›Full record

ArticlePediatric blood & cancer2022

Neurocognitive functioning in preschool children with sickle cell disease.

Andrew M Heitzer, Diana L Cohen, Victoria I Okhomina, Ana Trpchevska, Brian Potter, Jennifer Longoria, Jerlym S Porter, Jeremie H Estepp, Allison King, Misham Henley and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06562439 (Early Identification and Intervention Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease Using the Sickle Cell Caregiver Collaboration for Child Development), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06562439 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Early Identification and Intervention Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease Using the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2028Enrolled0ConditionsSickle Cell DiseaseArmsSickle Cell Collaboration for Child Development
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew M HeitzerDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-0582-3850
Diana L CohenDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Victoria I OkhominaDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ana TrpchevskaDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1302-0962
Brian PotterDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jennifer LongoriaDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jerlym S PorterDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jeremie H EsteppDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Allison KingProgram in Occupational Therapy and Department of Pediatrics and Medicine, Washington University, St. Louis, Missouri, USA.ORCID 0000-0002-1951-6176
Misham HenleyDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Guolian KangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jane S HankinsDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-4439-7321

Funding

MR-Derived Cerebral Oxygen Metabolism underlying Ischemic Vulnerability in Sickle Cell DiseaseR01HL129241 · NHLBI · WASHINGTON UNIVERSITY · PI Hongyu An, Robert A Campbell · 2015 to 2026
$6.6M
The Implementation of Cognitive Screening and Educational Support to Improve Outcomes of Adolescents and Young Adults with Sickle Cell Disease: From Clinic to the Community and BackU01HL133994 · NHLBI · WASHINGTON UNIVERSITY · PI KING, ALLISON A · 2016 to 2021
$5.2M
RE-aiming at Hydroxyurea Adherence for Sickle cell with mHealth (RE-HASH)U01HL133996 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HANKINS, JANE SILVA, KLESGES, LISA M · 2016 to 2021
$4.6M
Washington University K12 Program in T4 Implementation ResearchK12HL137942 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G. · 2017 to 2021
$3.1M
Implementation of evidence based care for the acute treatment of sickle cell disease painU01HL143477 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BROUSSEAU, DAVID C · 2018 to 2019
$1.1M
Identification of Predictors and Outcomes of Sickle Cell Health Care TransitionK01HL125495 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PORTER, JERLYM S · 2016 to 2020
$767k
(SCANS) Sickle Cell Anemia Neurodevelopmental Screening - Mentoring and Research in Patient Oriented ResearchK24HL148305 · NHLBI · WASHINGTON UNIVERSITY · PI Allison A King · 2019 to 2026
$706k
NHLBI NIH HHS K01 HL125495NHLBI NIH HHS K12 HL137942NHLBI NIH HHS K24 HL148305NHLBI NIH HHS R01 HL129241NHLBI NIH HHS U01 HL133994NHLBI NIH HHS U01 HL133996NHLBI NIH HHS U01 HL143477
6 · The paper itself

Abstract

backgroundChildren with sickle cell disease (SCD) experience neurodevelopmental delays; however, there is limited research with preschool-age children. This study examined neurocognitive risk and protective factors in preschoolers with SCD. PROCEDURE: Sixty-two patients with SCD (60% HbSS/HbSβ

resultsPatients with HbSS/HbSβ

conclusionsPreschoolers with severe SCD (HbSS/HbSβ

Indexed as

Anemia, Sickle CellHemoglobin SC DiseaseThalassemiaChildChild, PreschoolHemoglobin, SickleHumansHydroxyureaHemoglobin, SickleHydroxyureahydroxyureaneurocognitionneurodevelopmentpreschoolsickle cell diseasesocial determinantssocioeconomic status

Identifiers

PMID34971013
PMCPMC9207743

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.