ArticleJournal of the American Heart Association2022
Association Between Arousals During Sleep and Hypertension Among Patients With Obstructive Sleep Apnea.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Cardiovascular effects after five nights without continuous positive airway pressure for obstructive sleep apnea: a randomized controlled trial.Journal of hypertension · 2025Trial
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Apnea-Hypopnea Index Versus Hypoxic Burden as Predictors of Blood Pressure Response to Continuous Positive Airway Pressure Treatment in Patients With Obstructive Sleep Apnoe.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Redefining Obstructive Sleep Apnea: Multidimensional Phenotyping Beyond the Apnea-Hypopnea Index.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Sleep Fragmentation, Not Nocturnal Hypoxemia, Is the Primary Correlate of Attentional Slowing in Obstructive Sleep Apnea.Journal of personalized medicine · 2026Article
- Predicting Significant Blood Pressure Reduction Through Ambulatory Blood Pressure Monitoring in Patients With Obstructive Sleep Apnea Treated With Continuous Positive Airway Pressure.The clinical respiratory journal · 2026Article
- Hypoxic burden as a cause of cardiovascular morbidity in childhood obstructive sleep apnea.Pediatric research · 2026Article
- Article
- Actigraphy-derived sleep fragmentation index: convergent validity and associations with clinical outcomes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics.European journal of medical research · 2025Article
- Intermittent Hypoxia as a Model of Obstructive Sleep Apnea: Present and Future.Sleep medicine clinics · 2025Review
- Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia With the Circadian Rhythm of Myocardial Infarction.Journal of the American Heart Association · 2025Observational
- Sleep disruption and sleep position: Increased wake frequency in supine predicts lateral position preference.Journal of sleep research · 2025Article
- Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting.Reviews in cardiovascular medicine · 2025Article
- Validation of sleep-staging accuracy for an in-home sleep electroencephalography device compared with simultaneous polysomnography in patients with obstructive sleep apnea.Scientific reports · 2024Article
- Characterisation of Symptom and Polysomnographic Profiles Associated with Cardiovascular Risk in a Sleep Clinic Population with Obstructive Sleep Apnoea.Nature and science of sleep · 2024Article
- Blood pressure control in hypertensive sleep apnoea patients of the European Sleep Apnea Database cohort - effects of positive airway pressure and antihypertensive medication.European heart journal open · 2023Article
- Effect of Sleep Duration on Blood Pressure in Patients with SARS-CoV-2 Infection and Hypertensive Urgencies in Shanghai Fangcang Shelter Hospital.Infection and drug resistance · 2023Article
- Advances in animal models of obstructive sleep apnea.Frontiers in medicine · 2023Review
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Sleep fragmentation induced by repetitive arousals is a hallmark of obstructive sleep apnea (OSA). Sleep fragmentation has been linked to hypertension in community-based studies, but it is unclear if this association is manifest in OSA. We aimed to explore whether frequent arousals from sleep modify the relationship between OSA and prevalent hypertension. Methods and Results A total of 10 102 patients with OSA and 1614 primary snorers were included in the study. Hypertension was defined on either direct blood pressure measures or diagnosis by a physician. Spontaneous, respiratory, and movement arousals were derived by polysomnography. Logistic regression models were used to estimate the associations between arousals and prevalent hypertension in patients with OSA and primary snorers. For every 10-unit increase of total arousal index, odds of hypertension significantly increased in both the total sample (odds ratio [OR], 1.08; 95% CI, 1.03-1.14;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.