Evidence map›Paper›PMID 34970835›Full record

ArticleHuman brain mapping2022

Identifying a whole-brain connectome-based model in drug-naïve Parkinson's disease for predicting motor impairment.

Haoting Wu, Cheng Zhou, Xueqin Bai, Xiaocao Liu, Jingwen Chen, Jiaqi Wen, Tao Guo, Jingjing Wu, Xiaojun Guan, Ting Gao and 5 more

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Haoting WuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Cheng ZhouDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xueqin BaiDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaocao LiuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jingwen ChenDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jiaqi WenDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Tao GuoDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jingjing WuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaojun GuanDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ting GaoDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Luyan GuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Peiyu HuangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaojun XuDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Baorong ZhangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Minming ZhangDepartment of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0003-0145-7558
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying a whole-brain connectome-based predictive model in drug-naïve patients with Parkinson's disease and verifying its predictions on drug-managed patients would be useful in determining the intrinsic functional underpinnings of motor impairment and establishing general brain-behavior associations. In this study, we constructed a predictive model from the resting-state functional data of 47 drug-naïve patients by using a connectome-based approach. This model was subsequently validated in 115 drug-managed patients. The severity of motor impairment was assessed by calculating Unified Parkinson's Disease Rating Scale Part III scores. The predictive performance of model was evaluated using the correlation coefficient (r

Indexed as

ConnectomeMotor DisordersParkinson DiseaseBrainHumansMagnetic Resonance Imagingbrain connectomemotor impairmentParkinson's diseasepredictionsresting-state fMRI

Identifiers

PMID34970835
PMCPMC8933250
OpenAlexW4206674279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.