Evidence map›Paper›PMID 34970783›Full record

ArticleJournal of clinical laboratory analysis2022

Predictive value of lymphocyte-to-monocyte ratio in critically Ill patients with atrial fibrillation: A propensity score matching analysis.

Yue Yu, Suyu Wang, Pei Wang, Qiumeng Xu, Yufeng Zhang, Jian Xiao, Xiaofei Xue, Qian Yang, Wang Xi, Junnan Wang and 3 more

Abstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Monocyte-to-lymphocyte ratio is a prognostic predictor for patients with non-small cell lung cancer treated with stereotactic body radiation therapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yue YuDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Suyu WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Pei WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Qiumeng XuDepartment of Orthopaedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yufeng ZhangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jian XiaoDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiaofei XueDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Qian YangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Wang XiDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Junnan WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Renhong HuangDepartment of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Meiyun LiuDepartment of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Zhinong WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0001-6308-7949

Funding

Medical Science and Technology Youth Cultivation Plan NO.17QNP013National Nature Science Foundation of China NO.81770244Shanghai Municipal Commission of Science and Technology NO.17ZR1439100Shanghai Science and Technology Committee Medicine Leading Project NO.15411960100Shanghai Shenkang Medicine Developing Project NO.SHDC12014107
6 · The paper itself

Abstract

backgroundInflammation plays a key role in the initiation and progression of atrial fibrillation (AF). Lymphocyte-to-monocyte ratio (LMR) has been proved to be a reliable predictor of many inflammation-associated diseases, but little data are available on the relationship between LMR and AF. We aimed to evaluate the predictive value of LMR in predicting all-cause mortality among AF patients.

methodsData of patients diagnosed with AF were retrieved from the Medical Information Mart for Intensive Care-III (MIMIC-III) database. X-tile analysis was used to calculate the optimal cutoff value for LMR. The Cox regression model was used to assess the association of LMR and 28-day, 90-day, and 1-year mortality. Additionally, a propensity score matching (PSM) method was performed to minimize the impact of potential confounders.

resultsA total of 3567 patients hospitalized with AF were enrolled in this study. The X-tile software indicated that the optimal cutoff value of LMR was 2.67. A total of 1127 pairs were generated, and all the covariates were well balanced after PSM. The Cox proportional-hazards model showed that patients with the low LMR (≤2.67) had a higher 1-year all-cause mortality than those with the high LMR (>2.67) in the study cohort before PSM (HR = 1.640, 95% CI: 1.437-1.872, p < 0.001) and after PSM (HR = 1.279, 95% CI: 1.094-1.495, p = 0.002). The multivariable Cox regression analysis for 28-day and 90-day mortality yielded similar results.

conclusionsThe lower LMR (≤2.67) was associated with a higher risk of 28-day, 90-day, and 1-year all-cause mortality, which might serve as an independent predictor in AF patients.

Indexed as

LymphocytesMonocytesPropensity ScoreAgedAged, 80 and overAtrial FibrillationFemaleHumansLeukocyte CountMalePrognosisProportional Hazards Modelsatrial fibrillationinflammationlymphocyte-to-monocyte ratioMIMIC-III databasemortalityprognostic biomarkerregression analysis

Identifiers

PMID34970783
PMCPMC8842191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.