ArticleJournal of mathematical biology2021
Global asymptotic stability of the active disassembly model of flagellar length control.
Article in Journal of mathematical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Organelle size control is a fundamental question in biology that demonstrates the fascinating ability of cells to maintain homeostasis within their highly variable environments. Theoretical models describing cellular dynamics have the potential to help elucidate the principles underlying size control. Here, we perform a detailed study of the active disassembly model proposed in Fai et al. (elife 8:e42599, 2019). We construct a hybrid system which is shown to be well-behaved throughout the domain. We rule out the possibility of oscillations arising in the model and prove global asymptotic stability in the case of two flagella by the construction of a suitable Lyapunov function. Finally, we generalize the model to the case of arbitrary flagellar number in order to study olfactory sensory neurons, which have up to twenty cilia per cell. We show that our theoretical results may be extended to this case and explore the implications of this universal mechanism of size control.
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