Evidence map›Paper›PMID 34970677›Full record

SynthesisPediatrics2022

Cardiovascular Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.

Peta M A Alexander, Paul A Checchia, Lindsay M Ryerson, Desmond Bohn, Michelle Eckerle, Michael Gaies, Peter Laussen, Howard Jeffries, Ravi R Thiagarajan, Lara Shekerdemian and 4 more

Open access · greenAbstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 3 countries.

Peta M A AlexanderDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
Paul A ChecchiaSection of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas.
Lindsay M RyersonDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Desmond BohnDepartment of Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Michelle EckerleDepartment of Pediatrics, College of Medicine, University of Cincinnati and Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Michael GaiesDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan.
Peter LaussenDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
Howard JeffriesDepartment of Pediatrics, School of Medicine, University of Washington, Seattle, Washington.
Ravi R ThiagarajanDepartment of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
Lara ShekerdemianSection of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas.
Melania M BembeaDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Jerry J ZimmermanDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Seattle Children's Hospital and Harborview Medical Center and School of Medicine, University of Washington, Seattle, Washington.
Niranjan KissoonDivision of Critical Care, Department of Pediatrics, The University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Harvard University · USTexas Children's Hospital · USUniversity of Washington · USBC Children's Hospital · CACincinnati Children's Hospital Medical Center · USHospital for Sick Children · CAJohns Hopkins University · USUniversity of Alberta · CAUniversity of Michigan · USUniversity of Zurich · CH

Funding

Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation (ECMO)R01NS106292 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BEMBEA, MELANIA MARIA · 2019 to 2023
$3.1M
NINDS NIH HHS R01 NS106292
6 · The paper itself

Abstract

contextCardiovascular dysfunction is associated with poor outcomes in critically ill children.

objectiveWe aim to derive an evidence-informed, consensus-based definition of cardiovascular dysfunction in critically ill children. DATA SOURCES: Electronic searches of PubMed and Embase were conducted from January 1992 to January 2020 using medical subject heading terms and text words to define concepts of cardiovascular dysfunction, pediatric critical illness, and outcomes of interest. STUDY SELECTION: Studies were included if they evaluated critically ill children with cardiovascular dysfunction and assessment and/or scoring tools to screen for cardiovascular dysfunction and assessed mortality, functional status, organ-specific, or other patient-centered outcomes. Studies of adults, premature infants (≤36 weeks gestational age), animals, reviews and/or commentaries, case series (sample size ≤10), and non-English-language studies were excluded. Studies of children with cyanotic congenital heart disease or cardiovascular dysfunction after cardiopulmonary bypass were excluded. DATA EXTRACTION: Data were abstracted from each eligible study into a standard data extraction form, along with risk-of-bias assessment by a task force member.

resultsCardiovascular dysfunction was defined by 9 elements, including 4 which indicate severe cardiovascular dysfunction. Cardiopulmonary arrest (>5 minutes) or mechanical circulatory support independently define severe cardiovascular dysfunction, whereas tachycardia, hypotension, vasoactive-inotropic score, lactate, troponin I, central venous oxygen saturation, and echocardiographic estimation of left ventricular ejection fraction were included in any combination. There was expert agreement (>80%) on the definition. LIMITATIONS: All included studies were observational and many were retrospective.

conclusionsThe Pediatric Organ Dysfunction Information Update Mandate panel propose this evidence-informed definition of cardiovascular dysfunction.

Indexed as

Cardiovascular DiseasesCardiovascular SystemChildCritical IllnessHumansMultiple Organ FailureOrgan Dysfunction Scores

Identifiers

PMID34970677
PMCPMC9745438
OpenAlexW4205818096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.