Evidence map›Paper›PMID 34970674›Full record

SynthesisPediatrics2022

Immune System Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.

Mark W Hall, Joseph A Carcillo, Timothy Cornell, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative

Open access · greenAbstract readSystematic ReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mark W HallDivision of Critical Care Medicine, Department of Pediatrics, College of Medicine, The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio.
Joseph A CarcilloDivision of Pediatric Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh and Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.
Timothy CornellDivision of Pediatric Critical Care Medicine, Department of Pediatrics, School of Medicine, Stanford University and Lucile Packard Children's Hospital Stanford, Palo Alto, California.
Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Children's Hospital of Pittsburgh · USNationwide Children's Hospital · USStanford University · US

Funding

Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure RenewalR01GM108618 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOSEPH A CARCILLO · 2014 to 2026
$5.4M
NIGMS NIH HHS R01 GM108618
6 · The paper itself

Abstract

contextImmune system dysfunction is poorly represented in pediatric organ dysfunction definitions.

objectiveTo evaluate evidence for criteria that define immune system dysfunction in critically ill children and associations with adverse outcomes and develop consensus criteria for the diagnosis of immune system dysfunction in critically ill children. DATA SOURCES: We conducted electronic searches of PubMed and Embase from January 1992 to January 2020, using medical subject heading terms and text words to define immune system dysfunction and outcomes of interest. STUDY SELECTION: Studies of critically ill children with an abnormality in leukocyte numbers or function that is currently measurable in the clinical laboratory in which researchers assessed patient-centered outcomes were included. Studies of adults or premature infants, animal studies, reviews and commentaries, case series (≤10 subjects), and studies not published in English with inability to determine eligibility criteria were excluded. DATA EXTRACTION: Data were abstracted from eligible studies into a standard data extraction form along with risk of bias assessment by a task force member.

resultsWe identified the following criteria for immune system dysfunction: (1) peripheral absolute neutrophil count <500 cells/μL, (2) peripheral absolute lymphocyte count <1000 cells/μL, (3) reduction in CD4+ lymphocyte count or percentage of total lymphocytes below age-specific thresholds, (4) monocyte HLA-DR expression <30%, or (5) reduction in ex vivo whole blood lipopolysaccharide-induced TNFα production capacity below manufacturer-provided thresholds. LIMITATIONS: Many measures of immune system function are currently limited to the research environment.

conclusionsWe present consensus criteria for the diagnosis of immune system dysfunction in critically ill children.

Indexed as

ChildCritical IllnessHLA-DR AntigensHumansImmune SystemImmune System DiseasesLeukocyte CountLymphocyte CountLymphopeniaMultiple Organ FailureNeutropeniaNeutrophilsSeverity of Illness IndexTumor Necrosis Factor-alphaHLA-DR AntigensTNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID34970674
PMCPMC9166150
OpenAlexW4206439334

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.