Evidence map›Paper›PMID 34970611›Full record

ArticleFrontiers in cardiovascular medicine2021

A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection.

Prasanta K Dash, Fadhel A Alomar, Jesse L Cox, JoEllyn McMillan, Bryan T Hackfort, Edward Makarov, Brenda Morsey, Howard S Fox, Howard E Gendelman, Santhi Gorantla and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Prasanta K DashDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Fadhel A AlomarDepartment of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Jesse L CoxDepartments of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
JoEllyn McMillanDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Bryan T HackfortDepartments of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, United States.
Edward MakarovDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Brenda MorseyDepartments of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Howard S FoxDepartments of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States.
Howard E GendelmanDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Santhi GorantlaDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
Keshore R BidaseeDepartments of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States.
University of Nebraska Medical Center · USImam Abdulrahman Bin Faisal University · SA

Funding

Targeted lipid nanoparticles for gene therapeutics delivery approach to eradicating HIV reservoirsR01MH121402 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Benson Edagwa, Howard E Gendelman · 2019 to 2026
$4.9M
LASER ART for PrePR01AI158160 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI EDAGWA, BENSON, GENDELMAN, HOWARD E · 2021 to 2025
$3.5M
Diastolic Heart Failure in HIV-1 infectionR01HL164306 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BIDASEE, KESHORE R, GORANTLA, SANTHI · 2022 to 2024
$1.9M
NHLBI NIH HHS R01 HL164306NIAID NIH HHS R01 AI158160NIMH NIH HHS R01 MH121402
6 · The paper itself

Abstract

Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg-Prkdc

Indexed as

echocardiographyheart failureHIV-1humanized micemethylglyoxal

Identifiers

PMID34970611
PMCPMC8712558
OpenAlexW4200250186

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.