Evidence map›Paper›PMID 34970415›Full record

ArticleOxidative medicine and cellular longevity2021

ELK1 Promotes Epithelial-Mesenchymal Transition and the Progression of Lung Adenocarcinoma by Upregulating B7-H3.

Ting-Ting Yu, Tao Zhang, Fei Su, Ying-Long Li, Li Shan, Xiao-Ming Hou, Ruo-Zheng Wang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ting-Ting YuDepartment of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
Tao ZhangDepartment of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Fei SuDepartment of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Ying-Long LiDepartment of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
Li ShanDepartment of Thoracic Oncology, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
Xiao-Ming HouDepartment of Oncology, The First Hospital of Lanzhou University, Lanzhou 730000, China.ORCID https://orcid.org/0000-0002-8521-749X
Ruo-Zheng WangRadiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.ORCID https://orcid.org/0000-0003-0127-4436
Xinjiang Medical University · CNFirst Hospital of Lanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In previous studies, we found that B7 homolog 3 (B7-H3) was highly expressed in lung adenocarcinoma (LUAD) and promoted epithelial-to-mesenchymal transition (EMT) of LUAD cells. However, the underlying molecular mechanism is unclear. This study is aimed at evaluating the role of Ets-like protein 1 (ELK1) as a transcriptional regulator of B7-H3 for mediating the development and progression of LUAD

Indexed as

Adenocarcinoma of LungAgedAnimalsB7 AntigensCell ProliferationDisease Models, AnimalEpithelial-Mesenchymal Transitionets-Domain Protein Elk-1HumansLung NeoplasmsMiceMice, NudeMiddle AgedTransfectionUp-RegulationB7 AntigensCd276 protein, mouseElk1 protein, mouseets-Domain Protein Elk-1

Identifiers

PMID34970415
PMCPMC8714344
OpenAlexW4200415960

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.