Evidence map›Paper›PMID 34970299›Full record

ArticleFrontiers in genetics2021

Protein Function Prediction Based on PPI Networks: Network Reconstruction vs Edge Enrichment.

Jiaogen Zhou, Wei Xiong, Yang Wang, Jihong Guan

Abstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  7. Graph Neural Network-Based Approaches for Protein Function Prediction.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  8. Article
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  17. Identification of the function ofTranslational cancer research · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiaogen ZhouJiangsu Provincial Engineering Research Center for Intelligent Monitoring and Ecological Management of Pond and Reservoir Water Environment, Huaiyin Normal University, Huian, China.
Wei XiongShanghai Key Lab of Intelligent Information Processing, and School of Computer Science, Fudan University, Shanghai, China.
Yang WangDepartment of Computer Science and Technology, Tongji University, Shanghai, China.
Jihong GuanDepartment of Computer Science and Technology, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decades, massive amounts of protein-protein interaction (PPI) data have been accumulated due to the advancement of high-throughput technologies, and but data quality issues (noise or incompleteness) of PPI have been still affecting protein function prediction accuracy based on PPI networks. Although two main strategies of

Indexed as

edge enrichmentnetwork reconstructionprotein function predictionprotein-protein interaction networksprotein sequence annotation

Identifiers

PMID34970299
PMCPMC8712557

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.