ReviewFrontiers in psychiatry2021
Emotional Blunting in Patients With Major Depressive Disorder: A Brief Non-systematic Review of Current Research.
Review in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Turkish Validation of the Oxford Depression Questionnaire: Psychometric and Clinical Evidence Across Healthy, Drug-Naïve, and Remitted Medicated Depression Groups.The Psychiatric quarterly · 2026Article
- Association Between Self-Reported Pornographic Consumption Habits and Anxiety and Depression: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Comparative multidimensional psychosocial profiles of major depressive disorder patients with higher versus lower anhedonia burden: a cross-sectional study.BMC psychiatry · 2026Article
- Emotional Blunting in Hong Kong Patients with Major Depressive Disorder Treated with Vortioxetine: A Naturalistic Observational Study.Biomedicines · 2026Article
- Depression prediction and key factors: A comparative analysis of logistic regression and machine learning models.PloS one · 2026Article
- The METOD study: exploring metabolism, emotional blunting and treatment outcomes in depression - A naturalistic, two-phase observational protocol.Frontiers in pharmacology · 2026Article
- Trazodone effectiveness in depression (TED): a comparative evaluation of effect sizes trazodone extended release and SSRIs in the treatment of major depressive disorder.Frontiers in pharmacology · 2026Article
- Investigating the dose-response relationship between music and anxiety reduction: A randomized clinical trial.PLOS mental health · 2026Article
- Therapeutic modulation of empathy: pharmacological, neurostimulation, and behavioral approaches.Frontiers in psychology · 2026Review
- Depressed mood as a transdiagnostic target relevant to anxiety and/or psychosis: a scoping review.BMJ open · 2025Article
- Phase 1 clinical trial on Orgasmic Meditation (OM): Assessing safety and feasibility as a meditation practice for individuals with PTSD.Contemporary clinical trials communications · 2025Article
- Optimizing the diagnosis and treatment of depression in primary care: the emerging role of vortioxetine treatment.Frontiers in psychiatry · 2025Article
- Identification and experimental validation of biomarkers associated with mitochondrial and programmed cell death in major depressive disorder.Frontiers in psychiatry · 2025Article
- Multimodal Mental Health Digital Biomarker Analysis From Remote Interviews Using Facial, Vocal, Linguistic, and Cardiovascular Patterns.IEEE journal of biomedical and health informatics · 2024Article
- Article
- Negative emotionality downregulation affects moral choice but not moral judgement of harm: a pharmacological study.Scientific reports · 2024Article
- Adverse Childhood Experiences and Depression among Homeless Young Adults: A Social Determinants of Health Perspective.International journal of environmental research and public health · 2024Article
- A Delphi consensus on clinical features, diagnosis and treatment of major depressive disorder patients with anhedonia amongst psychiatrists in the Asia-Pacific.Frontiers in psychiatry · 2024Article
- Anhedonia in Major Depressive Disorder: Prevalence and Treatment Expectations and Satisfaction with Treatment Goals Among Patients and Physicians in Asia-Pacific.Neuropsychiatric disease and treatment · 2024Article
- Development of a multivariate prediction model for antidepressant resistant depression using reward-related predictors.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emotional blunting is frequently reported by patients with major depressive disorder (MDD) and has been identified as one of the most prominent side effects of antidepressants leading to medication discontinuation. However, antidepressant-induced emotional blunting remains largely unexplored-there lacks a clinical definition of this condition, and no agreeing conclusion has been reached regarding its etiology. Current research suggests that the onset of diminished emotional response may be related to antidepressant dose, with higher doses being more likely to induce emotional blunting. Consequently, most clinicians either reduce the dose or switch to another drug when treating this symptom. Overall, more comprehensive clinical assessments or interviews specifically designed to evaluate antidepressant-induced emotional blunting in MDD patients are in need to elucidate the neuropsychological mechanisms behind this increasingly prevalent symptom.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.