Evidence map›Paper›PMID 34969958›Full record

ArticleScientific reports2021

Bleeding management in computed tomography-guided liver biopsies by biopsy tract plugging with gelatin sponge slurry.

Nikolaus A Handke, Dennis C Koch, Eugen Muschler, Daniel Thomas, Julian A Luetkens, Ulrike I Attenberger, Daniel Kuetting, Claus C Pieper, Kai Wilhelm

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Technical considerations in endoscopic ultrasound-guided liver biopsy: A comprehensive review.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nikolaus A Handke *Department of Radiology, Johanniter-Hospital Bonn, Bonn, Germany. Nikolaus.Handke@ukbonn.de.
Dennis C Koch *Department of Radiology, Johanniter-Hospital Bonn, Bonn, Germany.
Eugen MuschlerDepartment of Radiology, Johanniter-Hospital Bonn, Bonn, Germany.
Daniel ThomasDepartment of Radiology, University Hospital Bonn, Bonn, Germany.
Julian A LuetkensDepartment of Radiology, University Hospital Bonn, Bonn, Germany.
Ulrike I AttenbergerDepartment of Radiology, University Hospital Bonn, Bonn, Germany.
Daniel KuettingDepartment of Radiology, University Hospital Bonn, Bonn, Germany.
Claus C PieperDepartment of Radiology, University Hospital Bonn, Bonn, Germany.
Kai WilhelmDepartment of Radiology, Johanniter-Hospital Bonn, Bonn, Germany.
University Hospital Bonn · DEJohanniter-Krankenhaus Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the safety and impact of biopsy tract plugging with gelatin sponge slurry in percutaneous liver biopsy. 300 consecutive patients (158 females, 142 males; median age, 63 years) who underwent computed tomography-guided core biopsy of the liver in coaxial technique (16/18 Gauge) with and without biopsy tract plugging were retrospectively reviewed (January 2013 to May 2018). Complications were rated according to the common criteria for adverse events (NCI-CTCAE). The study cohort was dichotomized into a plugged (71%; n = 214) and an unplugged (29%; n = 86) biopsy tract group. Biopsy tract plugging with gelatin sponge slurry was technically successful in all cases. Major bleeding events were only observed in the unplugged group (0.7%; n = 2), whereas minor bleedings (4.3%) were observed in both groups (plugged, 3.6%, n = 11; unplugged, 0.7%, n = 2). Analysis of biopsies and adverse events showed a significant association between number of needle-passes and overall (P = 0.038; odds ratio: 1.395) as well as minor bleeding events (P = 0.020; odds ratio: 1.501). No complications associated with gelatin sponge slurry were observed. Biopsy tract plugging with gelatin sponge slurry is a technically easy and safe procedure that can prevent major bleeding events following liver biopsy.

Indexed as

Image-Guided BiopsyTomography, X-Ray ComputedAdultAgedAged, 80 and overBiocompatible MaterialsFemaleGelatinHemorrhageHumansLiverMaleMiddle AgedRetrospective StudiesBiocompatible MaterialsGelatin

Identifiers

PMID34969958
PMCPMC8718535
OpenAlexW4200424229

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.