Evidence map›Paper›PMID 34969868›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Emotional Context Sculpts Action Goal Representations in the Lateral Frontal Pole.

Regina C Lapate, Ian C Ballard, Marisa K Heckner, Mark D'Esposito

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06276400 (Lateral Prefrontal Organization in Emotion), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06276400 narecruitingnot on this mapstarted 2024, after this paper: background citation

Lateral Prefrontal Organization in Emotion: Representational and Causal Mechanism - Duration Difference Estimation

TypeinterventionalSponsorUniversity of California, Santa BarbaraRan2024 to 2028Enrolled50ConditionsHealthyArmsEmotion valence, Time, TMS Stimulation
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Evidence for Abstract Codes in Parietal Cortex Guiding Prospective Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Neural Patterns Reflect Shared Emotional History.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Regina C LapateDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California 93106 lapate@ucsb.edu.ORCID 0000-0002-1835-2309
Ian C BallardHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.
Marisa K HecknerInstitute of Neuroscience and Medicine, Research Centre Jülich, 52428 Jülich, Germany.
Mark D'EspositoHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720.ORCID 0000-0002-3462-006X
University of California, Berkeley · USForschungszentrum Jülich · DEUniversity of California, Santa Barbara · US

Funding

Working Memory and Prefrontal CortexR01MH063901 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI D'ESPOSITO, MARK · 2001 to 2022
$7.6M
Causal mechanisms of habitual rule selectionF32MH119796 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALLARD, IAN CONNORS · 2020 to 2022
$201k
Representational code and causal mechanisms of prefrontal regulation of emotionF32MH113347 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI LAPATE, REGINA · 2017 to 2019
$179k
NIMH NIH HHS F32 MH113347NIMH NIH HHS F32 MH119796NIMH NIH HHS R01 MH063901
6 · The paper itself

Abstract

Emotional states provide an ever-present source of contextual information that should inform behavioral goals. Despite the ubiquity of emotional signals in our environment, the neural mechanisms underlying their influence on goal-directed action remains unclear. Prior work suggests that the lateral frontal pole (FPl) is uniquely positioned to integrate affective information into cognitive control representations. We used pattern similarity analysis to examine the content of representations in FPl and interconnected mid-lateral prefrontal and amygdala circuitry. Healthy participants (

Indexed as

EmotionsGoalsAmygdalaBrain MappingFemaleFrontal LobeHumansMagnetic Resonance ImagingMalePrefrontal Cortexcognitive controlemotionemotion–cognition interactionslateral frontal poleprefrontal organizationrepresentational similarity analysis

Identifiers

PMID34969868
PMCPMC8883870
OpenAlexW4220726626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.