Evidence map›Paper›PMID 34969861›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Flexibility of telomerase in binding the RNA template and DNA telomeric repeat.

Woo Suk Choi, Peter J Weng, Wei Yang

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. A degenerate telomerase RNA directs telomeric DNA synthesis in lepidopteran insects.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Telomerase structural biology comes of age.Current opinion in structural biology · 2022
    Review
  4. Visualization of mutagenic nucleotide processing byProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Woo Suk ChoiLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.ORCID 0000-0002-2651-5833
Peter J WengLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
Wei YangLaboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892 weiy@niddk.nih.gov.ORCID 0000-0002-3591-2195
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Structural and mechanistic studies of translesion DNA synthesisZIADK036146 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YANG, WEI · 2009 to 2025
$7.7M
Structural and mechanistic studies of RNase H and HIV reverse transcriptaseZ01DK036144 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI YANG, WEI · 2007 to 2008
$601k
Intramural NIH HHS Z01 DK036144
6 · The paper itself

Abstract

Telomerase synthesizes telomeres at the ends of linear chromosomes by repeated reverse transcription from a short RNA template. Crystal structures of

Indexed as

TelomereAnimalsDNAProtein BindingRNATelomeraseTemplates, GeneticTriboliumDNARNATelomerasecavityDNA loopoutRNA-template translocationtelomeric repeat synthesistemplate-boundary element

Identifiers

PMID34969861
PMCPMC8740718
OpenAlexW4205995758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.