Evidence map›Paper›PMID 34969859›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Salima Bahri, Robert Silvers, Brian Michael, Kristaps Jaudzems, Daniela Lalli, Gilles Casano, Olivier Ouari, Anne Lesage, Guido Pintacuda, Sara Linse and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Breaking theACS measurement science au · 2026
    Article
  3. Article
  4. Aducanumab binding to AβProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Investigation of biomolecular dynamics by sensitivity-enhancedJournal of magnetic resonance open · 2024
    Article
  10. Review
  11. Article
  12. Characterization of dielectric properties and their impact on MAS-DNP NMR applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  13. Structural characterization of E22G AβPhysical chemistry chemical physics : PCCP · 2024
    Article
  14. Article
  15. Resonant Mixing Dynamic Nuclear Polarization.The journal of physical chemistry letters · 2023
    Article
  16. Article
  17. Frequency-swept dynamic nuclear polarization.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023
    Article
  18. Diamond rotors.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2023
    Article
  19. Article
  20. Conformational ensembles explain NMR spectra of frozen intrinsically disordered proteins.Protein science : a publication of the Protein Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Salima BahriDepartment of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Robert SilversDepartment of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Brian MichaelDepartment of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Kristaps JaudzemsCentre de Résonance Magnétique Nucléaire (RMN) à Très Hauts Champs, CNRS/École Normale Supérieure Lyon/Claude Bernard University Lyon 1, Université de Lyon, Villeurbanne 69100, France.ORCID 0000-0003-3922-2447
Daniela LalliCentre de Résonance Magnétique Nucléaire (RMN) à Très Hauts Champs, CNRS/École Normale Supérieure Lyon/Claude Bernard University Lyon 1, Université de Lyon, Villeurbanne 69100, France.
Gilles CasanoInstitut de Chimie Radicalaire, CNRS/Aix Marseille Université, Marseille 13013, France.
Olivier OuariInstitut de Chimie Radicalaire, CNRS/Aix Marseille Université, Marseille 13013, France.
Anne LesageCentre de Résonance Magnétique Nucléaire (RMN) à Très Hauts Champs, CNRS/École Normale Supérieure Lyon/Claude Bernard University Lyon 1, Université de Lyon, Villeurbanne 69100, France.
Guido PintacudaCentre de Résonance Magnétique Nucléaire (RMN) à Très Hauts Champs, CNRS/École Normale Supérieure Lyon/Claude Bernard University Lyon 1, Université de Lyon, Villeurbanne 69100, France.
Sara LinseDepartment of Chemistry, Lund University, Lund SE 22362, Sweden.ORCID 0000-0001-9629-7109
Robert G GriffinDepartment of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139; rgg@mit.edu.ORCID 0000-0003-1589-832X
Université Claude Bernard Lyon 1 · FRMassachusetts Institute of Technology · USCentre National de la Recherche Scientifique · FRFlorida State University · USLund University · SE

Funding

High Field DNP and EPR in Biological SystemsR01GM132997 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2019 to 2025
$4.6M
TR&D 4 -- Advanced Magic Angle Spinning NMR methodsP41GM132079 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2019 to 2021
$3.6M
Solid State NMR Studies of Amyloid ProteinsR01AG058504 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ROBERT Guy GRIFFIN · 2022 to 2026
$3.5M
Solid State NMR Studies of Amyloid ProteinsRF1AG058504 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2017 to 2017
$3.1M
NIA NIH HHS R01 AG058504NIA NIH HHS RF1 AG058504NIGMS NIH HHS P41 GM132079NIGMS NIH HHS R01 GM132997
6 · The paper itself

Abstract

Several publications describing high-resolution structures of amyloid-β (Aβ) and other fibrils have demonstrated that magic-angle spinning (MAS) NMR spectroscopy is an ideal tool for studying amyloids at atomic resolution. Nonetheless, MAS NMR suffers from low sensitivity, requiring relatively large amounts of samples and extensive signal acquisition periods, which in turn limits the questions that can be addressed by atomic-level spectroscopic studies. Here, we show that these drawbacks are removed by utilizing two relatively recent additions to the repertoire of MAS NMR experiments-namely,

Indexed as

Amyloid beta-PeptidesCarbon-13 Magnetic Resonance SpectroscopyPeptide FragmentsProtein ConformationProton Magnetic Resonance SpectroscopyTemperatureAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragments1H detectionamyloid β1-42dynamic nuclear polarizationmagic-angle spinning

Identifiers

PMID34969859
PMCPMC8740738
OpenAlexW4206484652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.