Evidence map›Paper›PMID 34969839›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains.

Zhouyang Shen, Kalina T Belcheva, Mark Jelcic, King Lam Hui, Anushka Katikaneni, Philipp Niethammer

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. cPLAScience advances · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. LYVAC/PDZD8 is a lysosomal vacuolator.Science (New York, N.Y.) · 2025
    Article
  9. The activation of INF2 by Piezo1/CaCurrent biology : CB · 2025
    Article
  10. DHRS7 Integrates NADPbioRxiv : the preprint server for biology · 2025
    Article
  11. Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Review
  13. Article
  14. The activation of INF2 by Piezo1/CabioRxiv : the preprint server for biology · 2024
    Article
  15. A Hierarchical Mechanotransduction System: From Macro to Micro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  16. Mechanics and functional consequences of nuclear deformations.Nature reviews. Molecular cell biology · 2022
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhouyang ShenCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Kalina T BelchevaBiochemistry, Cellular and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065.
Mark JelcicCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
King Lam HuiCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Anushka KatikaneniCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Philipp NiethammerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; niethamp@mskcc.org.ORCID 0000-0003-4175-4012
Memorial Sloan Kettering Cancer Center · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Chemical and Physical Mechanisms of Wound DetectionR35GM140883 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Philipp Michael Niethammer · 2021 to 2026
$3.8M
Biomechanical control of inflammation by the nuclear membraneR01GM127356 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI NIETHAMMER, PHILIPP MICHAEL · 2018 to 2021
$1.6M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM127356NIGMS NIH HHS R35 GM140883
6 · The paper itself

Abstract

When nuclear membranes are stretched, the peripheral membrane enzyme cytosolic phospholipase A2 (cPLA

Indexed as

Group IV Phospholipases A2HumansLipid BilayersMechanotransduction, CellularNuclear EnvelopeProtein DomainsSurface TensionGroup IV Phospholipases A2Lipid BilayersPLA2G4A protein, humancalciumcPLA2mechanotransductionmembranenucleus

Identifiers

PMID34969839
PMCPMC8740744
OpenAlexW4200292324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.