ArticleProceedings of the National Academy of Sciences of the United States of America2022
Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Recombination shapes the dynamics of selective constraint in global populations of human gut bacteria.PLoS biology · 2026Article
- Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations.Nature communications · 2026Article
- Deciphering and steering population-level response under spatial drug heterogeneity on microhabitat structures.bioRxiv : the preprint server for biology · 2025Article
- Spatial sensing as a strategy for public goods regulation by gut microbes.The ISME journal · 2025Article
- Colon or semicolon: gut sampling microdevices for omics insights.NPJ biofilms and microbiomes · 2024Review
- Article
- Reversions mask the contribution of adaptive evolution in microbiomes.bioRxiv : the preprint server for biology · 2024Article
- The Non-Denatured Processing ofFoods (Basel, Switzerland) · 2024Article
- Modeling spatial evolution of multi-drug resistance under drug environmental gradients.PLoS computational biology · 2024Article
- Life at the borderlands: microbiomes of interfaces critical to One Health.FEMS microbiology reviews · 2024Review
- Spatial structure, chemotaxis and quorum sensing shape bacterial biomass accumulation in complex porous media.Nature communications · 2024Article
- Fluid flow structures gut microbiota biofilm communities by distributing public goods.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Emergent evolutionary forces in spatial models of luminal growth and their application to the human gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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3 authors.
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Abstract
The gut microbiota features important genetic diversity, and the specific spatial features of the gut may shape evolution within this environment. We investigate the fixation probability of neutral bacterial mutants within a minimal model of the gut that includes hydrodynamic flow and resulting gradients of food and bacterial concentrations. We find that this fixation probability is substantially increased, compared with an equivalent well-mixed system, in the regime where the profiles of food and bacterial concentration are strongly spatially dependent. Fixation probability then becomes independent of total population size. We show that our results can be rationalized by introducing an active population, which consists of those bacteria that are actively consuming food and dividing. The active population size yields an effective population size for neutral mutant fixation probability in the gut.
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