Evidence map›Paper›PMID 34969832›Full record

ArticleMolecular pharmacology2022

Cholesterol Inhibition of Slo1 Channels Is Calcium-Dependent and Can Be Mediated by Either High-Affinity Calcium-Sensing Site in the Slo1 Cytosolic Tail.

Kelsey C North, Man Zhang, Aditya K Singh, Dasha Zaytseva, Alexandria V Slayden, Anna N Bukiya, Alex M Dopico

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Progesterone activation of βNature communications · 2023
    Article
  6. Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  7. Cholesterol and PIPAdvances in experimental medicine and biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kelsey C NorthDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Man ZhangDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Aditya K SinghDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Dasha ZaytsevaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Alexandria V SlaydenDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Anna N BukiyaDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Alex M DopicoDepartment of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee adopico@uthsc.edu.
University of Tennessee Health Science Center · US

Funding

Regulation of arterial diameter through specific sensing of endogenous steroids and novel nonsteroidal analogs by BK channel subunitsR01HL147315 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI DOPICO, ALEX M. · 2019 to 2022
$2.4M
Cholesterol regulation of smooth muscle BK channel proteins and consequent control of cerebral artery diameterR01HL148941 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BUKIYA, ANNA, DOPICO, ALEX M. · 2020 to 2023
$2.4M
NHLBI NIH HHS R01 HL147315NHLBI NIH HHS R01 HL148941
6 · The paper itself

Abstract

Calcium- and voltage-gated K

Indexed as

AnimalsCalciumCalcium Channel BlockersCholesterolCytosolHEK293 CellsHumansLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMembrane PotentialsProtein Structure, SecondaryRatsCalciumCalcium Channel BlockersCholesterolKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID34969832
PMCPMC8969144
OpenAlexW4200588096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.