Evidence map›Paper›PMID 34969817›Full record

ArticleLife science alliance2022

Electron cryo-tomography structure of axonemal doublet microtubule from

Sam Li, Jose-Jesus Fernandez, Amy S Fabritius, David A Agard, Mark Winey

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
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  4. FAP20 is required for flagellum assembly inMolecular biology of the cell · 2024
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  8. FAP20 is required for flagellum assembly inbioRxiv : the preprint server for biology · 2024
    Article
  9. Article
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  11. Article
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  13. On the Unknown Proteins of Eukaryotic Proteomes.Journal of molecular evolution · 2023
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sam LiDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA sam.li@ucsf.edu.ORCID 0000-0002-0210-8192
Jose-Jesus FernandezNanomaterials and Nanotechnology Research Center (CINN-CSIC), Health Research Institute of Asturias (ISPA), Oviedo, Spain.ORCID 0000-0003-2222-3355
Amy S FabritiusDepartment of Molecular and Cellular Biology, University of California Davis, Davis, CA, USA.
David A AgardDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID 0000-0003-3512-695X
Mark WineyDepartment of Molecular and Cellular Biology, University of California Davis, Davis, CA, USA mwiney@ucdavis.edu.ORCID 0000-0002-9028-9033
University of California, Davis · USUniversity of California, San Francisco · USNanomaterials and Nanotechnology Research Center · ES

Funding

Structure & Mechanism: microtubule nucleation, centrosomes, phage cytoskeletonR35GM118099 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A. · 2016 to 2022
$3.6M
MIPS (Microtubule Inner Proteins) function in cilia and basal bodiesR01GM127571 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WINEY, MARK · 2018 to 2025
$2.5M
NIGMS NIH HHS R01 GM127571NIGMS NIH HHS R35 GM118099
6 · The paper itself

Abstract

Doublet microtubules (DMTs) provide a scaffold for axoneme assembly in motile cilia. Aside from α/β tubulins, the DMT comprises a large number of non-tubulin proteins in the luminal wall of DMTs, collectively named the microtubule inner proteins (MIPs). We used cryoET to study axoneme DMT isolated from

Indexed as

Tetrahymena thermophilaAxonemeBinding SitesMicrotubule ProteinsMicrotubulesModels, MolecularMutationProtein BindingProtein ConformationProtozoan ProteinsStructure-Activity RelationshipMicrotubule ProteinsProtozoan Proteins

Identifiers

PMID34969817
PMCPMC8742875
OpenAlexW4225365556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.