Evidence map›Paper›PMID 34969779›Full record

ArticleLife science alliance2022

Mammalian splicing divergence is shaped by drift, buffering in

Xudong Zou, Bernhard Schaefke, Yisheng Li, Fujian Jia, Wei Sun, Guipeng Li, Weizheng Liang, Tristan Reif, Florian Heyd, Qingsong Gao and 6 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Xudong ZouShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0002-2958-0438
Bernhard SchaefkeShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0003-1119-7198
Yisheng LiDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Fujian JiaDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Wei SunDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Guipeng LiShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Weizheng LiangDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Tristan ReifInstitute for Biochemistry, Freie Universität Berlin, Berlin, Germany.
Florian HeydInstitute for Biochemistry, Freie Universität Berlin, Berlin, Germany.
Qingsong GaoLaboratory for Systems Biology and Functional Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany.
Shuye TianShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yanping LiDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yisen TangDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Liang FangShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0003-4502-1756
Yuhui HuShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0002-5210-5301
Wei ChenShenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China chenw@sustech.edu.cn.ORCID 0000-0003-3263-1627
Southern University of Science and Technology · CNFreie Universität Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing is ubiquitous, but the mechanisms underlying its pattern of evolutionary divergence across mammalian tissues are still underexplored. Here, we investigated the

Indexed as

Evolution, MolecularGenetic DriftAlternative SplicingAnimalsDatabases, GeneticExonsFemaleHumansMaleMicePhenotypeRegulatory Sequences, Nucleic AcidRNA, MessengerRNA-SeqRNA, Messenger

Identifiers

PMID34969779
PMCPMC8739531
OpenAlexW4200119677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.