Evidence map›Paper›PMID 34969677›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing

Shreya Das, Mohd Saqib, Ryan C Meng, Sridar V Chittur, Ziqiang Guan, Fengyi Wan, Wei Sun

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Iron Metabolism and Immune Regulation.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Shreya DasDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208.ORCID 0000-0003-2184-2488
Mohd SaqibDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208.ORCID 0000-0002-3800-0490
Ryan C MengCenter for Functional Genomics, University at Albany-State University of New York, Rensselaer, NY 12144.
Sridar V ChitturCenter for Functional Genomics, University at Albany-State University of New York, Rensselaer, NY 12144.ORCID 0000-0001-8061-5846
Ziqiang GuanDepartment of Biochemistry, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-8082-3423
Fengyi WanDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205.ORCID 0000-0001-9216-9767
Wei SunDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208; sunw@amc.edu.ORCID 0000-0002-0071-6987
Albany Medical Center Hospital · USUniversity at Albany, State University of New York · USDuke Medical Center · USJohns Hopkins University · US

Funding

Yersinia Outer-Membrane-Vesicle Vaccines Against Pneumonic PlagueR01AI162670 · NIAID · ALBANY MEDICAL COLLEGE · PI Wei Sun · 2022 to 2026
$3.4M
Adaptive alterations of lipids in mitis group streptococciR01AI148366 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI GUAN, ZIQIANG, PALMER, KELLI LEA · 2020 to 2024
$2.5M
Yersinia pseudotuberculosis-based vaccines for plague and yersiniosisR01AI125623 · NIAID · UNIVERSITY OF FLORIDA · PI SUN, WEI · 2016 to 2020
$2.3M
Site-specific DNA recombinase and A/E pathogen virulenceR21AI137719 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WAN, FENGYI · 2019 to 2020
$450k
NIAID NIH HHS R01 AI125623NIAID NIH HHS R01 AI148366NIAID NIH HHS R21 AI137719
6 · The paper itself

Abstract

Hemachromatosis (iron-overload) increases host susceptibility to siderophilic bacterial infections that cause serious complications, but the underlying mechanisms remain elusive. The present study demonstrates that oral infection with hyperyersiniabactin (Ybt) producing

Indexed as

AnimalsBacterial ProteinsCalcium-Binding ProteinsCytokinesHemochromatosisInflammationInterleukin-1betaIntestinesMiceMyosin-Light-Chain KinaseNF-kappa BRepressor ProteinsSiderophoresSignal TransductionTranscriptomeYersinia pseudotuberculosisBacterial ProteinsCalcium-Binding ProteinsCytokinesInterleukin-1betaMyosin-Light-Chain KinaseNF-kappa BRepressor ProteinsSiderophoreshemochromatosishyperinflammationlethal infectionsiderophoreYersinia pseudotuberculosis

Identifiers

PMID34969677
PMCPMC8764673
OpenAlexW4205414925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.