Evidence map›Paper›PMID 34969584›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2022

Geographic Region, Racial/Ethnic Disparities, and Late-Life Depression: Results From a Large US Cohort of Older Adults.

Chirag M Vyas, Charles F Reynolds, Macarius Donneyong, David Mischoulon, Grace Chang, Nancy R Cook, JoAnn E Manson, Olivia I Okereke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Chirag M VyasDepartment of Psychiatry (CMV, DM, OIO), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Charles F ReynoldsDepartment of Psychiatry (CFR), UPMC, and University of Pittsburgh School of Medicine, Pittsburgh, PA.
Macarius DonneyongCollege of Pharmacy (MD), The Ohio State University, Columbus, OH.
David MischoulonDepartment of Psychiatry (CMV, DM, OIO), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Grace ChangDepartment of Psychiatry (GC), VA Boston Healthcare System and Harvard Medical School, Boston, MA.
Nancy R CookDivision of Preventive Medicine, Department of Medicine (NRC, JAEM), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology (NRC, JAEM, OIO), Harvard T.H. Chan School of Public Health, Boston, MA.
JoAnn E MansonDivision of Preventive Medicine, Department of Medicine (NRC, JAEM), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology (NRC, JAEM, OIO), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine (JAEM, OIO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Olivia I OkerekeDepartment of Psychiatry (CMV, DM, OIO), Massachusetts General Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology (NRC, JAEM, OIO), Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine (JAEM, OIO), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. Electronic address: Olivia.Okereke@MGH.HARVARD.EDU.
Harvard University · USBrigham and Women's Hospital · USMassachusetts General Hospital · USThe Ohio State University · USUniversity of Pittsburgh · US

Funding

VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F · 2011 to 2015
$8.3M
VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaLR01MH091448 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI OKEREKE, OLIVIA IFEOMA · 2010 to 2019
$6.5M
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint PainR01AR059086 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI COSTENBADER, KAREN H · 2010 to 2021
$5.4M
The VITamin D and OmegA-3 TriaL (VITAL): Post-Intervention Follow-UpR01AT011729 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI Jun Li, JoAnn Elisabeth Manson · 2021 to 2026
$5.2M
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney diseaseR01DK088762 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H · 2010 to 2019
$4.7M
Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and HypertensionR01HL102122 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FORMAN, JOHN P, SESSO, HOWARD D · 2011 to 2016
$3.3M
Lung VITamin D and OmegA-3 TriaL (Lung VITAL)R01HL101932 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R · 2010 to 2014
$3.2M
A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive DeclineR01AG036755 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KANG, JAE H · 2010 to 2015
$2.6M
Diabetes Prevention in the Vitamin D and Omega-3 TrialR01DK088078 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI PRADHAN, ARUNA DAS, SONG, YIQING · 2010 to 2014
$2.4M
Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on FracturesR01AR060574 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2010 to 2013
$779k
NCCIH NIH HHS R01 AT011729NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NHLBI NIH HHS R01 HL101932NHLBI NIH HHS R01 HL102122NIAMS NIH HHS R01 AR059086NIAMS NIH HHS R01 AR060574NIA NIH HHS R01 AG036755NIDDK NIH HHS R01 DK088078NIDDK NIH HHS R01 DK088762NIMH NIH HHS P30 MH090333NIMH NIH HHS R01 MH091448
6 · The paper itself

Abstract

objectivesTo determine associations between geographic region and late-life depression (LLD) severity, item-level symptom burden, and treatment; to evaluate whether racial/ethnic disparities in LLD, previously observed in the overall sample, vary by region.

methodsWe included 25,502 VITAL (Vitamin D and Omega-3 Trial) participants and administered the Patient Health Questionnaire-8 for depressive symptoms; participants also reported medication and/or counseling care for depression. Multivariable regression analyses were performed.

resultsDespite overall lower LLD severity and item-level symptom burden in the Midwest versus Northeast, higher LLD severity and item-level burden were observed among minorities, especially Black and Hispanic adults, compared to non-Hispanic whites in this region. Racial/ethnic disparities in item-level symptoms (e.g., anhedonia, sadness, psychomotor changes) varied by region. There were no significant differences in depression care by region; furthermore, regional variation was not observed in racial disparities in care: e.g., among those with clinician/physician-diagnosed depression, Blacks versus non-Hispanic whites had greater than 50% lower odds of treatment in all regions.

conclusionLLD varied by geographic region. Furthermore, magnitudes of racial/ethnic disparities in LLD severity and item-level symptom burden, but not depression care, differed by region.

Indexed as

DepressionEthnicityAgedHealthcare DisparitiesHispanic or LatinoHumansRacial GroupsUnited StatesWhite PeopledepressionGeographyrace/ethnicityolder adults

Identifiers

PMID34969584
PMCPMC9106835
OpenAlexW3216760969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.