Evidence map›Paper›PMID 34969358›Full record

ArticleBioengineered2022

Lipocalin-2 silencing suppresses inflammation and oxidative stress of acute respiratory distress syndrome by ferroptosis via inhibition of MAPK/ERK pathway in neonatal mice.

Xiaodong Wang, Chunhua Zhang, Na Zou, Qinghua Chen, Chaojun Wang, Xu Zhou, Li Luo, Haibin Qi, Junhua Li, Zhiyan Liu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 110 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Xiaodong WangDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Chunhua ZhangDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Na ZouDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Qinghua ChenDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Chaojun WangDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Xu ZhouDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Li LuoDepartment of Pediatrics, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Haibin QiDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Junhua LiDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Zhiyan LiuUltrasonographic Department, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Jinghong YiDepartment of Neonatology, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Jing LiDepartment of Science and Education, Yichang Maternal and Child Health Care Hospital, Clinical Medical College of Women and Children, Three Gorges University, Yichang, China.
Wei LiuDepartment of Neonatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
China Three Gorges University · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal acute respiratory distress syndrome (ARDS) has high morbidity and mortality rates worldwide, but there is a lack of pharmacologic treatment and clinical targeted therapies. In this study, we aimed to explore the effects of Lipocalin-2 (LCN2) on ferroptosis-mediated inflammation and oxidative stress in neonatal ARDS and the potential mechanism. In this study, we established an in vivo ARDS mouse model and an in vitro ARDS cell model by LPS (Lipopolysaccharide) stimulation. Lung tissue injury was evaluated by wet/dry ratios and histopathological examination. LCN2 expression was detected by qRT-PCR and Western blot. Inflammatory factors, oxidative stress and apoptosis were also detected. Ferroptosis was identified by detection of Fe

Indexed as

FerroptosisAnimalsAnimals, NewbornDisease Models, AnimalGene SilencingLipocalin-2LipopolysaccharidesMAP Kinase Signaling SystemMiceOxidative StressRandom AllocationRespiratory Distress Syndrome, NewbornRNA, Small InterferingSignal TransductionUp-RegulationLcn2 protein, mouseLipocalin-2LipopolysaccharidesRNA, Small InterferingAcute respiratory distress syndromeferroptosisLipocalin-2MAPK/ERK pathwayneonatal mice

Identifiers

PMID34969358
PMCPMC8805876
OpenAlexW4206523090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.