Evidence map›Paper›PMID 34968705›Full record

ArticleFree radical biology & medicine2022

Mitochondrial superoxide targets energy metabolism to modulate epigenetic regulation of NRF2-mediated transcription.

Sanjit K Dhar, Timothy Scott, Chi Wang, Teresa W M Fan, Daret K St Clair

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sanjit K DharDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0509, USA. Electronic address: Sanjit.dhar@uky.edu.
Timothy ScottMarkey Cancer Center, University of Kentucky, Lexington, KY, 40536-0509, USA. Electronic address: Tim.Scott@uky.edu.
Chi WangMarkey Cancer Center, University of Kentucky, Lexington, KY, 40536-0509, USA. Electronic address: Chi.wang@uky.edu.
Teresa W M FanDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0509, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0509, USA. Electronic address: Teresa.fan@uky.edu.
Daret K St ClairDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0509, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, 40536-0509, USA. Electronic address: dstcl00@uky.edu.
University of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
University of Kentucky Center for Cancer MetabolismP20GM121327 · NIGMS · UNIVERSITY OF KENTUCKY · PI Jianhang Jia · 2017 to 2026
$25.0M
SAMPLE COREU24DK097215 · NIDDK · UNIVERSITY OF KENTUCKY · PI FAN, TERESA WHEI-MEI, HIGASHI, RICHARD M · 2013 to 2017
$8.7M
A redox-mediated mechanism of UVB-induced metabolic switch in skin carcinogenesisR01CA214638 · NCI · UNIVERSITY OF KENTUCKY · PI ST CLAIR, DARET K · 2018 to 2022
$2.0M
NCI NIH HHS P30 CA177558NCI NIH HHS R01 CA214638NIDDK NIH HHS U24 DK097215NIGMS NIH HHS P20 GM121327
6 · The paper itself

Abstract

Mitochondria are central to the metabolic circuitry that generates superoxide radicals/anions (O

Indexed as

HistonesSuperoxidesAcetylationEnergy MetabolismEpigenesis, GeneticHumansMitochondriaNF-E2-Related Factor 2HistonesNF-E2-Related Factor 2SuperoxidesEpigeneticsMetabolismMitochondriaSuperoxideTCA cycleTranscription

Identifiers

PMID34968705
PMCPMC8765599
OpenAlexW4200492811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.