Evidence map›Paper›PMID 34968623›Full record

SynthesisCritical reviews in oncology/hematology2022

Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations.

Stefano Tamburin, Susanna B Park, Angelo Schenone, Elisa Mantovani, Mehrnaz Hamedani, Paola Alberti, Vesile Yildiz-Kabak, Ian R Kleckner, Noah Kolb, Miryam Mazzucchelli and 5 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical reviews in oncology/hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
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  20. Motor disorders related to oxaliplatin-induced peripheral neuropathy: long-term severity and impact on quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefano TamburinDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy. Electronic address: stefano.tamburin@univr.it.
Susanna B ParkBrain and Mind Centre, Faculty of Medicine and Health, University of Sydney, New South Wales, Australia.
Angelo SchenoneDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genoa, Italy; IRCCS San Martino Hospital, Genoa, Italy.
Elisa MantovaniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.
Mehrnaz HamedaniDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences (DINOGMI), University of Genoa, Italy.
Paola AlbertiExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Vesile Yildiz-KabakFaculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey.
Ian R KlecknerDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Noah KolbDepartment of Neurological Sciences, University of Vermont, Burlington, VT, USA.
Miryam MazzucchelliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Brendan L McNeishDepartment of Neurological Sciences, University of Vermont, Burlington, VT, USA.
Andreas A ArgyriouDepartment of Neurology, "Saint Andrew's" State General Hospital of Patras, Patras, Greece.
Guido CavalettiExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Ahmet HokeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Toxic Neuropathy Consortium

Funding

The Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy, Inflammation, and Interoceptive Brain CircuitryK07CA221931 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT · 2018 to 2022
$795k
Assessing the role of the interoceptive brain system in the pathophysiology and treatment of chemotherapy-induced peripheral neuropathyR21CA256154 · NCI · UNIVERSITY OF ROCHESTER · PI KLECKNER, IAN ROBERT, LIN, PO-JU · 2021 to 2021
$351k
NCI NIH HHS K07 CA221931NCI NIH HHS R21 CA256154
6 · The paper itself

Abstract

Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy, and other physical non-pharmacological interventions and offered evidence-based recommendations for the prevention and treatment of CIPN. A literature search using PubMed, Web of Science and CINAHL was conducted from database inception until May 31st, 2021. 2791 records were title-abstract screened, 71 papers were full-text screened, 41 studies were included, 21 on prevention and 20 on treatment of CIPN. Treatment type, cancer type, chemotherapy compounds were heterogeneous, sample size was small (median: N = 34) and intention-to-treat analysis was lacking in 26/41 reports. Because of the methodological issues of included studies, the reviewed evidence should be considered as preliminary. Exercise, endurance, strength, balance, and sensorimotor training have been studied in low-to-moderate quality studies, while the evidence for other treatments is preliminary/inconclusive. We offer recommendation for the design of future trials on CIPN.

Indexed as

Antineoplastic AgentsNeoplasmsPeripheral Nervous System DiseasesExerciseHumansAntineoplastic AgentsChemotherapy-induced peripheral neurotoxicity (CIPN)Evidence-based medicineExercisePhysical therapyRehabilitationTreatment

Identifiers

PMID34968623
PMCPMC10658987

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.