ReviewInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2022
Dementia ConnEEGtome: Towards multicentric harmonization of EEG connectivity in neurodegeneration.
Review in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer's disease.Alzheimer's research & therapy · 2023Pooled it
- Generalizability of EEG-Based DEMENTIA Classifiers: A Multicenter study of Alzheimer's, MCI, and FTD.medRxiv : the preprint server for health sciences · 2026Article
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- Comprehensive methodology for sample enrichment in EEG biomarker studies for Alzheimer's risk classification.PloS one · 2026Article
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- Merging multimodal digital biomarkers into "Digital Neuro Fingerprints" for precision neurology in dementias: the promise of the right treatment for the right patient at the right time in the age of AI.Frontiers in digital health · 2025Article
- Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.Nature medicine · 2024Article
- Structural inequality and temporal brain dynamics across diverse samples.Clinical and translational medicine · 2024Article
- Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity in response to an acute somatic nociceptive heel lance stimulus.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Brain health in diverse settings: How age, demographics and cognition shape brain function.NeuroImage · 2024Article
- Brain clocks capture diversity and disparity in aging and dementia.Research square · 2024Article
- Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: A Turkish Study.Brain sciences · 2024Article
- Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Electrophysiological alterations during action semantic processing in Parkinson's disease.Neurobiology of aging · 2024Article
- Quantitative electroencephalography (qEEG), apolipoprotein A-I (APOA-I), and apolipoprotein epsilon 4 (APOE ɛ4) alleles for the diagnosis of mild cognitive impairment and Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Multivariate word properties in fluency tasks reveal markers of Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neurophysiological markers of early cognitive decline in older adults: a mini-review of electroencephalography studies for precursors of dementia.Frontiers in aging neuroscience · 2024Review
- Alzheimer's disease diagnosis using rhythmic power changes and phase differences: a low-density EEG study.Frontiers in aging neuroscience · 2024Article
- Elevating understanding: Linking high-altitude hypoxia to brain aging through EEG functional connectivity and spectral analyses.Network neuroscience (Cambridge, Mass.) · 2024Article
- DIVA Meets EEG: Model Validation Using Formant-Shift Reflex.Applied sciences (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 6 countries.
Funding
Abstract
The proposal to use brain connectivity as a biomarker for dementia phenotyping can be potentiated by conducting large-scale multicentric studies using high-density electroencephalography (hd- EEG). Nevertheless, several barriers preclude the development of a systematic "ConnEEGtome" in dementia research. Here we review critical sources of variability in EEG connectivity studies, and provide general guidelines for multicentric protocol harmonization. We describe how results can be impacted by the choice for data acquisition, and signal processing workflows. The implementation of a particular processing pipeline is conditional upon assumptions made by researchers about the nature of EEG. Due to these assumptions, EEG connectivity metrics are typically applicable to restricted scenarios, e.g., to a particular neurocognitive disorder. "Ground truths" for the choice of processing workflow and connectivity analysis are impractical. Consequently, efforts should be directed to harmonizing experimental procedures, data acquisition, and the first steps of the preprocessing pipeline. Conducting multiple analyses of the same data and a proper integration of the results need to be considered in additional processing steps. Furthermore, instead of using a single connectivity measure, using a composite metric combining different connectivity measures brings a powerful strategy to scale up the replicability of multicentric EEG connectivity studies. These composite metrics can boost the predictive strength of diagnostic tools for dementia. Moreover, the implementation of multi-feature machine learning classification systems that include EEG-based connectivity analyses may help to exploit the potential of multicentric studies combining clinical-cognitive, molecular, genetics, and neuroimaging data towards a multi-dimensional characterization of the dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.