Evidence map›Paper›PMID 34968409›Full record

ArticleIslets2022

LDB1-mediated transcriptional complexes are sensitive to islet stress.

Yanping Liu, Jessica D Kepple, Anath Shalev, Chad S Hunter

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Islets, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yanping LiuDepartment of Medicine, Division of Endocrinology Diabetes and Metabolism University of Alabama at Birmingham, Birmingham, AL, USA.
Jessica D KeppleDepartment of Medicine, Division of Endocrinology Diabetes and Metabolism University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-0600-2045
Anath ShalevDepartment of Medicine, Division of Endocrinology Diabetes and Metabolism University of Alabama at Birmingham, Birmingham, AL, USA.
Chad S HunterDepartment of Medicine, Division of Endocrinology Diabetes and Metabolism University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1644-447X
University of Alabama at Birmingham · US

Funding

TXNIP REGULATION OF ENDOGENOUS BETA CELL MASSR01DK078752 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI SHALEV, ANATH · 2008 to 2021
$4.4M
Revealing LIM Domain Transcriptional Complexes that establish and maintain Beta Cell MassR01DK111483 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Chad S Hunter · 2017 to 2026
$3.4M
A novel link between gene regulation and histone modifications governing islet beta-cell development and functionR01DK128132 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HUNTER, CHAD S · 2022 to 2025
$1.9M
Illuminating novel roles for the Ldb1 co-regulator in transcriptional regulation of brown adipose functionF31DK121414 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEPPLE, JESSICA · 2019 to 2021
$121k
NIDDK NIH HHS F31 DK121414NIDDK NIH HHS R01 DK078752NIDDK NIH HHS R01 DK111483NIDDK NIH HHS R01 DK128132
6 · The paper itself

Abstract

Excess nutrients and proinflammatory cytokines impart stresses on pancreatic islet β-cells that, if unchecked, can lead to cellular dysfunction and/or death. Among these stress-induced effects is loss of key β-cell transcriptional regulator mRNA and protein levels required for β-cell function. Previously, our lab and others reported that LIM-domain complexes comprised the LDB1 transcriptional co-regulator and Islet-1 (ISL1) transcription factor are required for islet β-cell development, maturation, and function. The LDB1:ISL1 complex directly occupies and regulates key β-cell genes, including

Indexed as

LIM Domain ProteinsTranscription FactorsAnimalsCytokinesDNA-Binding ProteinsGlucoseLIM-Homeodomain ProteinsMicePalmitatesRNA, MessengerCytokinesDNA-Binding ProteinsGlucoseLdb1 protein, mouseLIM Domain ProteinsLIM-Homeodomain ProteinsPalmitatesRNA, MessengerTranscription Factorsco-regulatorcytokinediabetesglucoseisletpalmitatepancreasTranscription factor

Identifiers

PMID34968409
PMCPMC8726731
OpenAlexW4205674978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.