Evidence map›Paper›PMID 34968368›Full record

ReviewEpigenomes2021

Evolution of CG Methylation Maintenance Machinery in Plants.

Louis Tirot, Pauline E Jullien, Mathieu Ingouff

Open access · diamondAbstract readReview
In one paragraph

Review in Epigenomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Louis TirotIPS, University of Bern, 3013 Bern, Switzerland.
Pauline E JullienIPS, University of Bern, 3013 Bern, Switzerland.ORCID 0000-0003-1212-3246
Mathieu IngouffCIRAD, DIADE, IRD, University of Montpellier, 34393 Montpellier, France.ORCID 0000-0002-6106-4564
University of Bern · CHCentre de Coopération Internationale en Recherche Agronomique pour le Développement · FR

Funding

Agence Nationale de la Recherche ANR-15- CE12-0012Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 163946
6 · The paper itself

Abstract

Cytosine methylation is an epigenetic mark present in most eukaryotic genomes that contributes to the regulation of gene expression and the maintenance of genome stability. DNA methylation mostly occurs at CG sequences, where it is initially deposited by de novo DNA methyltransferases and propagated by maintenance DNA methyltransferases (DNMT) during DNA replication. In this review, we first summarize the mechanisms maintaining CG methylation in mammals that involve the DNA Methyltransferase 1 (DNMT1) enzyme and its cofactor, UHRF1 (Ubiquitin-like with PHD and RING Finger domain 1). We then discuss the evolutionary conservation and diversification of these two core factors in the plant kingdom and speculate on potential functions of novel homologues typically observed in land plants but not in mammals.

Indexed as

DNA methylationDNA METHYLTRANSFERASE 1epigeneticsMET1plant

Identifiers

PMID34968368
PMCPMC8594673
OpenAlexW3199288395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.