Evidence map›Paper›PMID 34968301›Full record

ReviewEpigenomes2021

H3K4 Methylation in Aging and Metabolism.

Chia-Ling Hsu, Yi-Chen Lo, Cheng-Fu Kao

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epigenomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chia-Ling HsuInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
Yi-Chen LoGraduate Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan.
Cheng-Fu KaoInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-8875-8152
Institute of Cellular and Organismic Biology, Academia Sinica · TWNational Taiwan University · TW

Funding

Academia Sinica, Taiwan AS-108-TP-L07Ministry of Science and Technology, Taiwan MOST109-2320-B-001-017 -MY3
6 · The paper itself

Abstract

During the process of aging, extensive epigenetic alterations are made in response to both exogenous and endogenous stimuli. Here, we summarize the current state of knowledge regarding one such alteration, H3K4 methylation (H3K4me), as it relates to aging in different species. We especially highlight emerging evidence that links this modification with metabolic pathways, which may provide a mechanistic link to explain its role in aging. H3K4me is a widely recognized marker of active transcription, and it appears to play an evolutionarily conserved role in determining organism longevity, though its influence is context specific and requires further clarification. Interestingly, the modulation of H3K4me dynamics may occur as a result of nutritional status, such as methionine restriction. Methionine status appears to influence H3K4me via changes in the level of

Indexed as

agingH3K4 methylationmetabolism

Identifiers

PMID34968301
PMCPMC8594702
OpenAlexW3165970915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.