Evidence map›Paper›PMID 34968243›Full record

ArticleEpigenomes2020

Promoter and Terminator Optimization for DNA Methylation Targeting in

Jason Gardiner, Jenny M Zhao, Kendall Chaffin, Steven E Jacobsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Omics landscapes in molecular mechanisms withFood chemistry. Molecular sciences · 2025
    Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason GardinerDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, CA 90095, USA.ORCID 0000-0001-9387-6383
Jenny M ZhaoDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, CA 90095, USA.
Kendall ChaffinInstitute for Society and Genetics, University of California, Los Angeles, CA 90095, USA.
Steven E JacobsenDepartment of Molecular, Cell, and Developmental Biology, University of California Los Angeles, CA 90095, USA.ORCID 0000-0001-9483-138X

Funding

Bill and Melinda Gates Foundation OPP1210659
6 · The paper itself

Abstract

DNA methylation is an important epigenetic mark involved in gene regulation and silencing of transposable elements. The presence or absence of DNA methylation at specific sites can influence nearby gene expression and cause phenotypic changes that remain stable over generations. Recently, development of new technologies has enabled the targeted addition or removal of DNA methylation at specific sites of the genome. Of these new technologies, the targeting of the catalytic domain of

Indexed as

ArabidopsisDNA methylationepigeneticsplantpromoterRNA-directed DNA methylation (RdDM)silencingtargetingterminatortranscriptionzinc finger

Identifiers

PMID34968243
PMCPMC8594676

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.